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Gene Review

Cav2  -  caveolin 2

Rattus norvegicus

Synonyms: Caveolin-2
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Disease relevance of Cav2

  • Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2 [1].
  • Immunoblot analysis revealed that particulate fractions from rat C6 glioma cells express caveolin-1 and caveolin-2 [2].
  • As a model system, we chose caveolin-1alpha and caveolin-2, two major components of endothelial caveolae, and examined their interaction in the endothelium of vessels in fixed tissues of laboratory animals and human glomus tumors [3].
  • Two of these genes have been already related to obesity (adiponectin and caveolin-2) while the others are known to participate in metabolic, signalling or transcription regulation pathways that can be relevant in energy (lipid and/or carbohydrate) metabolism [4].

High impact information on Cav2

  • In addition, the lipid raft-dependent tyrosine phosphorylation of caveolin-2 appeared to be a critical regulator of P. aeruginosa invasion [1].
  • Moreover, P-gp interacts with caveolin-1 and caveolin-2; together, they form a high molecular mass complex [5].
  • Although caveolin-2 might be expected to interact in an fashion analogous to that of caveolin-3, it generally has not been detected in cardiomyocytes [6].
  • In neonatal cardiac cultures, caveolin-2 and -3 expression is not influenced by thyroid hormone (a postnatal regulator of other cardiac gene products) [6].
  • The regulatory function of caveolin-2 in cell cycle regulation by insulin was investigated in human insulin receptor-overexpressed rat 1 fibroblast (Hirc-B) cells [7].

Chemical compound and disease context of Cav2

  • Light-density, Triton X-100-insoluble caveolin-1- and caveolin-2-enriched fractions were obtained after fractionation of rat C6 glioma cells and their separation over 5-40% discontinuous sucrose-density gradients [2].

Biological context of Cav2


Anatomical context of Cav2


Associations of Cav2 with chemical compounds

  • Western blot and real-time RT-PCR analysis demonstrate that caveolin-1 and caveolin-2 are up-regulated during the late stages of the differentiation of C6 cells [13].
  • As bath application of amlodipine was ineffective to modify Cav2 channels in the sealed patch, we analyzed the channel activity when giga-seal formation was obtained in the presence of amlodipine (10 microM both in the pipette and bath solution) [11].
  • Cav2 channels, mainly composed of N-type channel in our experimental condition, were defined in this study as high voltage-activated Ca2+ channels obtained after selection of patches without L-type channel "mode 2" activity in the presence of 1 microM BayK8644, or L-type channel block by 5 microM nifedipine [11].
  • As shown by real-time RT-PCR and immunoblotting, bleomycin-treatment of R3/1 cells resulted in a decrease in mRNA and protein for both caveolin-1 and caveolin-2 in comparison with controls [14].

Other interactions of Cav2

  • Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3 [6].
  • After Northern blot validation of the results, only three genes appeared upregulated (caveolin-2, the alpha-1 chain of haemoglobin and rat mammary tumor-7) and two downregulated (adiponectin and dystroglycan) [9].

Analytical, diagnostic and therapeutic context of Cav2


  1. Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. Zaas, D.W., Duncan, M.J., Li, G., Wright, J.R., Abraham, S.N. J. Biol. Chem. (2005) [Pubmed]
  2. Identification of caveolae and caveolin in C6 glioma cells. Silva, W.I., Maldonado, H.M., Lisanti, M.P., Devellis, J., Chompré, G., Mayol, N., Ortiz, M., Velázquez, G., Maldonado, A., Montalvo, J. Int. J. Dev. Neurosci. (1999) [Pubmed]
  3. FRET-CLSM and double-labeling indirect immunofluorescence to detect close association of proteins in tissue sections. König, P., Krasteva, G., Tag, C., König, I.R., Arens, C., Kummer, W. Lab. Invest. (2006) [Pubmed]
  4. Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display. López, I.P., Milagro, F.I., Martí, A., Moreno-Aliaga, M.J., Martínez, J.A., De Miguel, C. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  5. P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins. Jodoin, J., Demeule, M., Fenart, L., Cecchelli, R., Farmer, S., Linton, K.J., Higgins, C.F., Béliveau, R. J. Neurochem. (2003) [Pubmed]
  6. Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Rybin, V.O., Grabham, P.W., Elouardighi, H., Steinberg, S.F. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  7. Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Kim, S., Pak, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. Characterisation of caveolins from cartilage: expression of caveolin-1, -2 and -3 in chondrocytes and in alginate cell culture of the rat tibia. Schwab, W., Galbiati, F., Volonte, D., Hempel, U., Wenzel, K.W., Funk, R.H., Lisanti, M.P., Kasper, M. Histochem. Cell Biol. (1999) [Pubmed]
  9. High-fat feeding period affects gene expression in rat white adipose tissue. Lopez, I.P., Milagro, F.I., Marti, A., Moreno-Aliaga, M.J., Martinez, J.A., De Miguel, C. Mol. Cell. Biochem. (2005) [Pubmed]
  10. Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. Shin, T., Kim, H., Jin, J.K., Moon, C., Ahn, M., Tanuma, N., Matsumoto, Y. J. Neuroimmunol. (2005) [Pubmed]
  11. Effects of amlodipine on unitary non-L-type high voltage-activated Ca2+ channel currents in differentiated PC12 cells. Hirano, Y., Orikabe, M., Hiraoka, M. Naunyn Schmiedebergs Arch. Pharmacol. (2001) [Pubmed]
  12. Differences in caveolae dynamics in vascular smooth muscle cells of different phenotypes. Thyberg, J. Lab. Invest. (2000) [Pubmed]
  13. Caveolin isoform expression during differentiation of C6 glioma cells. Silva, W.I., Maldonado, H.M., Velázquez, G., Rubio-Dávila, M., Miranda, J.D., Aquino, E., Mayol, N., Cruz-Torres, A., Jardón, J., Salgado-Villanueva, I.K. Int. J. Dev. Neurosci. (2005) [Pubmed]
  14. A new rat type I-like alveolar epithelial cell line R3/1: bleomycin effects on caveolin expression. Koslowski, R., Barth, K., Augstein, A., Tschernig, T., Bargsten, G., Aufderheide, M., Kasper, M. Histochem. Cell Biol. (2004) [Pubmed]
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