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Gene Review

CAV2  -  caveolin 2

Homo sapiens

Synonyms: CAV, Caveolin-2
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Disease relevance of CAV2


High impact information on CAV2


Chemical compound and disease context of CAV2


Biological context of CAV2


Anatomical context of CAV2


Associations of CAV2 with chemical compounds


Physical interactions of CAV2

  • Cav-2 was able to interact with Cav-1 in the Golgi complex but this interaction was not sufficient to export it from this compartment [11].
  • The finding of syndecan-2 reactive with caveolin-2/Ras suggests the molecular complex most likely to obstruct RACK1 for functional attachment at syndecan-2, as revealed in cells transfected with oncogenic ras [15].

Regulatory relationships of CAV2


Other interactions of CAV2

  • We found that CAV1, CAV2, MET and TES mRNA expression was lower in prostate tumors than in normal prostate tissues [18].
  • There was also a significant association between low CAV2 mRNA level and negative progesterone receptor status (P=0.013), and between high HER2/neu mRNA level and negative hormonal receptor status (ER, P=0.029, PgR, P=0.019) [3].
  • Caveolin-3 transcript levels increased in 82% of the cohort, along with a 2.5-fold induction of caveolin-2 [19].
  • Thus, caveolin-1 expression is required to stabilize the caveolin-2 protein product, to mediate the caveolar endocytosis of specific ligands, to negatively regulate the proliferation of certain cell types, and to provide tonic inhibition of eNOS activity in endothelial cells [12].
  • Western analysis demonstrated that mERhigh cells expressed caveolin-1 and caveolin-2, and that ER-alpha was contained in the same gradient-separated membrane fractions [20].

Analytical, diagnostic and therapeutic context of CAV2


  1. Herpes zoster in patients with carcinoma of the lung. Feld, R., Evans, W.K., DeBoer, G. Am. J. Med. (1982) [Pubmed]
  2. Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. Wikman, H., Seppänen, J.K., Sarhadi, V.K., Kettunen, E., Salmenkivi, K., Kuosma, E., Vainio-Siukola, K., Nagy, B., Karjalainen, A., Sioris, T., Salo, J., Hollmén, J., Knuutila, S., Anttila, S. J. Pathol. (2004) [Pubmed]
  3. Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer. Sagara, Y., Mimori, K., Yoshinaga, K., Tanaka, F., Nishida, K., Ohno, S., Inoue, H., Mori, M. Br. J. Cancer (2004) [Pubmed]
  4. Epithelial expression of caveolin-2, but not caveolin-1, is enhanced in the inflamed mucosa of patients with ulcerative colitis. Andoh, A., Saotome, T., Sato, H., Tsujikawa, T., Araki, Y., Fujiyama, Y., Bamba, T. Inflamm. Bowel Dis. (2001) [Pubmed]
  5. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. Fujimoto, T., Kogo, H., Ishiguro, K., Tauchi, K., Nomura, R. J. Cell Biol. (2001) [Pubmed]
  6. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. Galbiati, F., Volonte, D., Engelman, J.A., Watanabe, G., Burk, R., Pestell, R.G., Lisanti, M.P. EMBO J. (1998) [Pubmed]
  7. The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Sowa, G., Pypaert, M., Fulton, D., Sessa, W.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults. Kushner, B.H., Meyers, P.A., Gerald, W.L., Healey, J.H., La Quaglia, M.P., Boland, P., Wollner, N., Casper, E.S., Aledo, A., Heller, G. J. Clin. Oncol. (1995) [Pubmed]
  9. Comparative transductions of breast cancer cells by three DNA viruses. Lucas, A., Kremer, E.J., Hemmi, S., Luis, J., Vignon, F., Lazennec, G. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2. Fra, A.M., Pasqualetto, E., Mancini, M., Sitia, R. Gene (2000) [Pubmed]
  11. The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. Breuza, L., Corby, S., Arsanto, J.P., Delgrossi, M.H., Scheiffele, P., Le Bivic, A. J. Cell. Sci. (2002) [Pubmed]
  12. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. Razani, B., Engelman, J.A., Wang, X.B., Schubert, W., Zhang, X.L., Marks, C.B., Macaluso, F., Russell, R.G., Li, M., Pestell, R.G., Di Vizio, D., Hou, H., Kneitz, B., Lagaud, G., Christ, G.J., Edelmann, W., Lisanti, M.P. J. Biol. Chem. (2001) [Pubmed]
  13. Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. Burgermeister, E., Tencer, L., Liscovitch, M. Oncogene (2003) [Pubmed]
  14. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Yu, P., Yang, Z., Jones, J.E., Wang, Z., Owens, S.A., Mueller, S.C., Felder, R.A., Jose, P.A. Kidney Int. (2004) [Pubmed]
  15. Shift syndecan-2 from RACK1 to caveolin-2 upon transformation with oncogenic ras. Huang, J.W., Chuang, N.N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  16. Identification of caveolae and detection of caveolin in normal human osteoblasts. Lofthouse, R.A., Davis, J.R., Frondoza, C.G., Jinnah, R.H., Hungerford, D.S., Hare, J.M. The Journal of bone and joint surgery. British volume. (2001) [Pubmed]
  17. Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex. Parolini, I., Sargiacomo, M., Galbiati, F., Rizzo, G., Grignani, F., Engelman, J.A., Okamoto, T., Ikezu, T., Scherer, P.E., Mora, R., Rodriguez-Boulan, E., Peschle, C., Lisanti, M.P. J. Biol. Chem. (1999) [Pubmed]
  18. Extensive analysis of the 7q31 region in human prostate tumors supports TES as the best candidate tumor suppressor gene. Chêne, L., Giroud, C., Desgrandchamps, F., Boccon-Gibod, L., Cussenot, O., Berthon, P., Latil, A. Int. J. Cancer (2004) [Pubmed]
  19. Mechanical unloading increases caveolin expression in the failing human heart. Uray, I.P., Connelly, J.H., Frazier, O.H., Taegtmeyer, H., Davies, P.J. Cardiovasc. Res. (2003) [Pubmed]
  20. Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells. Zivadinovic, D., Watson, C.S. Breast Cancer Res. (2005) [Pubmed]
  21. Induction of alpha-caveolin-1 (alphaCAV1) expression in bovine granulosa cells in response to an ovulatory dose of human chorionic gonadotropin. Diouf, M.N., Lefebvre, R., Silversides, D.W., Sirois, J., Lussier, J.G. Mol. Reprod. Dev. (2006) [Pubmed]
  22. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. Scherer, P.E., Lewis, R.Y., Volonte, D., Engelman, J.A., Galbiati, F., Couet, J., Kohtz, D.S., van Donselaar, E., Peters, P., Lisanti, M.P. J. Biol. Chem. (1997) [Pubmed]
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