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Gene Review:

ATP1B3 - ATPase, Na+/K+ transporting, beta 3...

Homo sapiens

Synonyms: ATPB-3, CD298, FLJ29027, Sodium/potassium-dependent ATPase subunit beta-3, Sodium/potassium-transporting ATPase subunit beta-3

Malik, N. et al., Philibert, R.A. et al., Rozsa, F.W. et al., Chiampanichayakul, S. et al.

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Psychiatry related information on ATP1B3

Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish [1].

High impact information on ATP1B3

Two genes, ATP1B3 and COPB2, are of interest in the context of a protein-misfolding model for candidate selection [2].
Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells [3].
We have cloned and characterized the Na,K-ATPase beta 3 subunit gene (ATP1B3), and a beta 3 subunit pseudogene (ATP1B3P1), from a human PAC genomic library [4].

Biological context of ATP1B3

Fluorescence in situ hybridization with PAC DNA clones localized ATP1B3 to the q22-->23 region of Chromosome (Chr) 3, and the beta 3 pseudogene to the p13-->15 region of Chr 2 [4].

References

Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish. Philibert, R.A., Cheung, D., Welsh, N., Damschroder-Williams, P., Thiel, B., Ginns, E.I., Gershenfeld, H.K. Am. J. Med. Genet. (2001) [Pubmed]
Differential Expression Profile Prioritization of Positional Candidate Glaucoma Genes: The GLC1C Locus. Rozsa, F.W., Scott, K.M., Pawar, H., Samples, J.R., Wirtz, M.K., Richards, J.E. Arch. Ophthalmol. (2007) [Pubmed]
Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells. Chiampanichayakul, S., Khunkaewla, P., Pata, S., Kasinrerk, W. Tissue Antigens (2006) [Pubmed]
Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. Malik, N., Canfield, V., Sanchez-Watts, G., Watts, A.G., Scherer, S., Beatty, B.G., Gros, P., Levenson, R. Mamm. Genome (1998) [Pubmed]

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atp1b3a	Danio rerio
atp1b3b	Danio rerio
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