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ATP1B3P1  -  ATPase, Na+/K+ transporting, beta 3...

Homo sapiens

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Disease relevance of ATP1B3P1

  • We have previously reported the cloning of a gene that encodes a copper transporting P-type ATPase (ATP7B) which is defective in Wilson disease [1].
  • Hepatic sodium-potassium-dependent ATPase in obesity [2].
  • Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome [3].
  • Examination of six patients with an "AIDS-related complex" revealed significantly reduced numbers of Langerhans' cells per square millimeter; this reduction was more pronounced in staining for Ia antigen (306 +/- 69) than in staining for ATPase activity (517 +/- 101) [3].
  • The putative proteasome-associated proteins Mpa (Mycobaterium proteasomal ATPase) and PafA (proteasome accessory factor A) of the human pathogen Mycobacterium tuberculosis (Mtb) are essential for virulence and resistance to nitric oxide [4].

Psychiatry related information on ATP1B3P1

  • Red blood cell Na+, K+-, Mg2+-, and Ca2+-adenosine triphosphatase (ATPase) activities were studied longitudinally in eight patients with affective disorders and 12 healthy volunteers [5].
  • Even though the mean Ca2+-ATPase activity was higher during manias and euthymic periods than during depressions, mood and ATPase activities did not correlate with each other in all patients [5].
  • We demonstrate that the insertion of the B2 sequence reduces the motor activity of Dictyostelium myosin II, with reduction of the maximal actin-activated ATPase activity and a decrease in the affinity for actin [6].
  • Erythrocyte membrane Na+-K+ ATPase and Ca++ATPase levels were investigated in 11 women treated with ECT for endogenous depression and 11 age-matched normal control subjects [7].
  • Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome [8].

High impact information on ATP1B3P1

  • Of the 80% of oxygen consumption coupled to ATP synthesis, approximately 25-30% is used by protein synthesis, 19-28% by the Na(+)-K(+)-ATPase, 4-8% by the Ca2(+)-ATPase, 2-8% by the actinomyosin ATPase, 7-10% by gluconeogenesis, and 3% by ureagenesis, with mRNA synthesis and substrate cycling also making significant contributions [9].
  • Mutations in the gene-encoding SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease [10].
  • Furthermore, studies using the ATP analog, ATP gamma S, suggest either that protein phosphorylation alone is sufficient for dispersion or that transport is mediated by a unique force-generating ATPase that can use ATP gamma S for hydrolyzable energy [11].
  • Sequence analysis indicated that TURF 2H3 originated by recombinations among portions of the flanking and/or coding regions of the maize mitochondrial 26S ribosomal gene, the ATPase subunit 6 gene, and the chloroplast tRNA-Arg gene [12].
  • The AAA domain, a conserved Walker-type ATPase module, is a feature of members of the AAA family of proteins, which are involved in many cellular processes, including vesicular transport, organelle biogenesis, microtubule rearrangement and protein degradation [13].

Chemical compound and disease context of ATP1B3P1


Biological context of ATP1B3P1


Anatomical context of ATP1B3P1

  • By immunofluorescence analysis using mAb P-3E10, it was found that all peripheral blood leukocytes express Na, K ATPase beta3 [23].
  • Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells [23].
  • The Ca2+-stimulated ATPase which is the enzymatic expression of this pump varies in its calcium sensitivity between different preparations of erythrocyte ghosts, with activation generally occurring in a concentration range between approximately 1 and 10 microM Ca2+ (refs 2--5) [24].
  • The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion [25].
  • DKH392, a construct containing two heads but no tails, has been shown to display both tight binding to microtubules and high ATPase rates [26].

Associations of ATP1B3P1 with chemical compounds

  • Upon phytohemagglutinin or phorbol myristate acetate activation, the expression level of the Na, K ATPase beta3 subunit on activated peripheral blood mononuclear cells was not altered in comparison with those of unstimulated cells [23].
  • It binds to microtubules under conditions of ATP depletion, possesses an ATPase activity and is sensitive to ultraviolet-induced, vanadate-dependent cleavage [27].
  • Orthovanadate, a powerful inhibitor of the (Na+ + K+)ATPase and the Na pump, also inhibits the Ca-stimulated ATPase activity, which is the enzymatic basis for the uncoupled Ca pump, in human red cells [28].
  • We localized the site of interaction to a single peptide isolated after cyanogen bromide cleavage of the ATPase [29].
  • Gle1 and the phosphoinositide IP6 activate Dbp5's ATPase activity in vitro and this could provide critical spatial regulation of Dbp5 activity in vivo [30].

Physical interactions of ATP1B3P1

  • hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha [31].
  • On the basis of sequence homology to known genes, the WD gene (ATP7B) appears to be a copper-transporting P-type ATPase [32].
  • The human Rad51 protein binds to single- and double-stranded DNA and exhibits DNA-dependent ATPase activity [33].
  • The Lymn-Taylor model for the actomyosin ATPase suggests that during each cycle of ATP hydrolysis the complex of myosin subfragment 1 (S-1) with actin must dissociate into S-1.ATP plus actin before ATP hydrolysis can occur [34].
  • The H+-translocating ATPase complex from the thermophilic bacterium PS3 (TF0-F1) is composed of a water-soluble part with ATP-hydrolyzing activity (TF1) and a membrane moiety with H+-conducting activity (TF0) [35].

Regulatory relationships of ATP1B3P1

  • The majority of P-glycoprotein mutants containing a single cysteine residue retained substantial amounts of drug-stimulated ATPase activity and were not inhibited by dBBn [36].
  • Calponin inhibits actomyosin Mg2+ ATPase and is proposed to regulate smooth muscle contraction; however, the mechanism by which it exerts its effect and the regulation of its behavior is still under investigation [37].
  • The delta pH is dissipated only under conditions in which the photosystem I turns, confirming that the thioredoxin must be reduced to activate the ATPase [38].
  • RESULTS: The mean Na+,K+ ATPase activity of peripheral blood mononuclear cells expressed as nanomoles per microgram protein per minute (nM/ microgram protein/ min) +/-1 standard deviation of the subjects with allergic rhinitis (n = 14) was 1.04 +/- 1.01, while that of the control subjects (n = 12) was 3.57 +/- 1.60 (P < or = .001) [39].
  • The antibodies raised against human erythrocyte Dnp-SG ATPase cross-reacted with the bovine lens epithelium Dnp-SG ATPase which was identified by Western blot as a band corresponding to an approximate M(r) value of 80,000 Da [40].

Other interactions of ATP1B3P1

  • The exon/intron organization of the beta 3 subunit gene is identical to that of the Na,K-ATPase beta 3 subunit gene, indicating that these two genes evolved from a common evolutionary ancestor [19].
  • The ATPase activity of hMutSalpha variants carrying the Lys-->Arg mutation in hMSH2 or in hMSH6 was severely affected, but these mutants were still proficient in mismatch binding and were able to complement, albeit to different extents, mismatch repair-deficient cell extracts [31].
  • (a) Serial sections were either incubated with anti-CA IV/FITC or processed for endothelial ATPase reaction [41].
  • The interaction not only reduced both the ATPase and the helicase activities of XPB purified in the baculovirus system but also impaired XPB-mediated cross-complementation of the repair deficiency in rodent UV-sensitive mutants of group 3 [42].
  • Mutation of lysine residue 798 in the DNA-dependent ATPase domain of BRG1 significantly reduced its ability to repress c-fos transcription [43].

Analytical, diagnostic and therapeutic context of ATP1B3P1

  • We report X-ray solution scattering and electron microscopy structures of the activated, full-length nitrogen-regulatory protein C (NtrC) showing a novel mechanism for regulation of AAA+ ATPase assembly via the juxtaposition of the receiver domains and ATPase ring [44].
  • Finally, recent biochemical dissection of the ATPase cycle and its coupling to protein unfolding has revealed fundamental operating principles of this important, ubiquitous family of molecular machines [45].
  • Immunoblotting analysis revealed a selective decrease in the amount of phospholamban protein, without a significant change in the content for either sarcoplasmic reticulum Ca2+ ATPase or calsequestrin, in the transgenic hearts compared with controls [46].
  • The immunoassay allows measurement of proton-pumping ATPase levels in human gastric biopsy specimens and may therefore be useful in studies of gastric mucosal function [47].
  • Indeed, axoplasm contains actin-dependent ATPase activity, and a pan-myosin antibody recognized at least four bands in Western blots of axoplasm [48].


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  3. Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome. Belsito, D.V., Sanchez, M.R., Baer, R.L., Valentine, F., Thorbecke, G.J. N. Engl. J. Med. (1984) [Pubmed]
  4. Identification of substrates of the Mycobacterium tuberculosis proteasome. Pearce, M.J., Arora, P., Festa, R.A., Butler-Wu, S.M., Gokhale, R.S., Darwin, K.H. EMBO J. (2006) [Pubmed]
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  8. Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome. Fergusson, J., Landon, M., Lowe, J., Dawson, S.P., Layfield, R., Hanger, D.P., Mayer, R.J. Neurosci. Lett. (1996) [Pubmed]
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  17. Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1{alpha}. Lim, J.H., Park, J.W., Kim, M.S., Park, S.K., Johnson, R.S., Chun, Y.S. Mol. Pharmacol. (2006) [Pubmed]
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  19. Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. Malik, N., Canfield, V., Sanchez-Watts, G., Watts, A.G., Scherer, S., Beatty, B.G., Gros, P., Levenson, R. Mamm. Genome (1998) [Pubmed]
  20. Elastic bending and active tilting of myosin heads during muscle contraction. Dobbie, I., Linari, M., Piazzesi, G., Reconditi, M., Koubassova, N., Ferenczi, M.A., Lombardi, V., Irving, M. Nature (1998) [Pubmed]
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  22. Mechanochemistry of transcription termination factor Rho. Adelman, J.L., Jeong, Y.J., Liao, J.C., Patel, G., Kim, D.E., Oster, G., Patel, S.S. Mol. Cell (2006) [Pubmed]
  23. Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells. Chiampanichayakul, S., Khunkaewla, P., Pata, S., Kasinrerk, W. Tissue Antigens (2006) [Pubmed]
  24. Human erythrocyte membranes exhibit a cooperative calmodulin-dependent Ca2+-ATPase of high calcium sensitivity. Downes, P., Michell, R.H. Nature (1981) [Pubmed]
  25. Occluded bound calcium on the phosphorylated sarcoplasmic transport ATPase. Takisawa, H., Makinose, M. Nature (1981) [Pubmed]
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  32. Identification and analysis of mutations in the Wilson disease gene (ATP7B): population frequencies, genotype-phenotype correlation, and functional analyses. Shah, A.B., Chernov, I., Zhang, H.T., Ross, B.M., Das, K., Lutsenko, S., Parano, E., Pavone, L., Evgrafov, O., Ivanova-Smolenskaya, I.A., Annerén, G., Westermark, K., Urrutia, F.H., Penchaszadeh, G.K., Sternlieb, I., Scheinberg, I.H., Gilliam, T.C., Petrukhin, K. Am. J. Hum. Genet. (1997) [Pubmed]
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  40. Low and high Km forms of dinitrophenylglutathione-stimulated ATPase in bovine lens. Kumari, K., Ansari, N.H., Saxena, M., Awasthi, Y.C., Srivastava, S.K. Exp. Eye Res. (1993) [Pubmed]
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  48. Evidence for myosin motors on organelles in squid axoplasm. Bearer, E.L., DeGiorgis, J.A., Bodner, R.A., Kao, A.W., Reese, T.S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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