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Gene Review

Catsup  -  Catecholamines up

Drosophila melanogaster

Synonyms: Bc, CG10449, Dmel\CG10449, Protein catecholamines up, catsup, ...
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Disease relevance of Catsup

  • The hyperactivation of TH in Catsup mutants results in abnormally high levels of catecholamines, which can account for the lethality, visible phenotypes, and female sterility observed in these mutants [1].

High impact information on Catsup


  1. The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity. Stathakis, D.G., Burton, D.Y., McIvor, W.E., Krishnakumar, S., Wright, T.R., O'Donnell, J.M. Genetics (1999) [Pubmed]
  2. Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila. Carbone, M.A., Jordan, K.W., Lyman, R.F., Harbison, S.T., Leips, J., Morgan, T.J., DeLuca, M., Awadalla, P., Mackay, T.F. Curr. Biol. (2006) [Pubmed]
  3. Ermelin, an endoplasmic reticulum transmembrane protein, contains the novel HELP domain conserved in eukaryotes. Suzuki, A., Endo, T. Gene (2002) [Pubmed]
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