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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

NTN3  -  netrin 3

Homo sapiens

Synonyms: NTN2L, Netrin-2-like protein, Netrin-3
 
 
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Disease relevance of NTN2L

 

High impact information on NTN2L

  • The NTN2L gene has a restricted pattern of expression; its transcript is undetectable by Northern analysis in all tissues examined, but can be recovered from spinal cord RNA by RT-PCR [1].
  • Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors [2].
 

Analytical, diagnostic and therapeutic context of NTN2L

  • The structure of the NTN2L gene has been confirmed utilizing nested RT-PCR [1].

References

  1. The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Van Raay, T.J., Foskett, S.M., Connors, T.D., Klinger, K.W., Landes, G.M., Burn, T.C. Genomics (1997) [Pubmed]
  2. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. Wang, H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Tessier-Lavigne, M. J. Neurosci. (1999) [Pubmed]
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