Disease relevance of Ntn2l

• Moreover, significant levels of netrin-3 protein were found to be associated with the axons projecting from these neurons suggesting a role for netrin-3 in axon pathfinding and fasciculation within the peripheral nervous system [1].

High impact information on Ntn2l

• We report here that myoblasts express the secreted factor netrin-3 and its receptor, neogenin [2].
• In contrast, Netrin-3 showed a prominent, distinct expression in the axon pathway and target field mesenchyme around the tooth [3].
• While the guidance potential of netrin-1 has been examined in depth in many regions of the developing mouse brain very little information is available on the expression and activity of netrin-3 [1].
• Here we show that the netrin-3 protein is present on motor neurons and subpopulations of neurons within sensory and sympathetic ganglia [1].
• In contrast to netrin-1 which is widely expressed both in the developing nervous system and in mesodermal tissues, netrin-3 transcripts are largely restricted to dorsal root ganglia and the developing limb buds [4].

Anatomical context of Ntn2l

• Netrin-3 is expressed in sensory ganglia, mesenchymal cells, and muscles during the time of peripheral nerve development but is largely excluded from the CNS at early stages of its development [5].
• In contrast, netrin-3, which is also expressed in the embryonic spinal cord, was not detected in the adult [6].

Associations of Ntn2l with chemical compounds

• We report the identification of a second mouse netrin gene, which we name netrin-3 [5].

References