Gene Review:
NTN1 - netrin 1
Homo sapiens
Synonyms:
Epididymis tissue protein Li 131P, NTN1L, Netrin-1
- Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. Kim, T.H., Lee, H.K., Seo, I.A., Bae, H.R., Suh, D.J., Wu, J., Rao, Y., Hwang, K.G., Park, H.T. J. Neurochem. (2005)
- Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Meyerhardt, J.A., Caca, K., Eckstrand, B.C., Hu, G., Lengauer, C., Banavali, S., Look, A.T., Fearon, E.R. Cell Growth Differ. (1999)
- Netrin-1 inhibits leukocyte migration in vitro and in vivo. Ly, N.P., Komatsuzaki, K., Fraser, I.P., Tseng, A.A., Prodhan, P., Moore, K.J., Kinane, T.B. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. Moon, C., Kim, H., Ahn, M., Jin, J.K., Wang, H., Matsumoto, Y., Shin, T. J. Neuroimmunol. (2006)
- The role of the floor plate in axon guidance. Colamarino, S.A., Tessier-Lavigne, M. Annu. Rev. Neurosci. (1995)
- Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Keino-Masu, K., Masu, M., Hinck, L., Leonardo, E.D., Chan, S.S., Culotti, J.G., Tessier-Lavigne, M. Cell (1996)
- Glial control of neuronal development. Lemke, G. Annu. Rev. Neurosci. (2001)
- Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Corset, V., Nguyen-Ba-Charvet, K.T., Forcet, C., Moyse, E., Chédotal, A., Mehlen, P. Nature (2000)
- Netrins: beyond the brain. Cirulli, V., Yebra, M. Nat. Rev. Mol. Cell Biol. (2007)
- UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Williams, M.E., Lu, X., McKenna, W.L., Washington, R., Boyette, A., Strickland, P., Dillon, A., Kaprielian, Z., Tessier-Lavigne, M., Hinck, L. Nat. Neurosci. (2006)
- Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. De Breuck, S., Lardon, J., Rooman, I., Bouwens, L. Diabetologia (2003)
- Quantification of expression of netrins, slits and their receptors in human prostate tumors. Latil, A., Chêne, L., Cochant-Priollet, B., Mangin, P., Fournier, G., Berthon, P., Cussenot, O. Int. J. Cancer (2003)
- Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by netrin-1 and slits. Lin, L., Isacson, O. Stem Cells (2006)
- Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. Kruger, R.P., Lee, J., Li, W., Guan, K.L. J. Neurosci. (2004)
- Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. de la Torre, J.R., Höpker, V.H., Ming, G.L., Poo, M.M., Tessier-Lavigne, M., Hemmati-Brivanlou, A., Holt, C.E. Neuron (1997)
- Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. Geisbrecht, B.V., Dowd, K.A., Barfield, R.W., Longo, P.A., Leahy, D.J. J. Biol. Chem. (2003)
- Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Lin, L., Rao, Y., Isacson, O. Mol. Cell. Neurosci. (2005)
- Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Yebra, M., Montgomery, A.M., Diaferia, G.R., Kaido, T., Silletti, S., Perez, B., Just, M.L., Hildbrand, S., Hurford, R., Florkiewicz, E., Tessier-Lavigne, M., Cirulli, V. Dev. Cell (2003)
- The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation. Tsai, N.P., Bi, J., Wei, L.N. EMBO J. (2007)
- DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation. Xie, Y., Hong, Y., Ma, X.Y., Ren, X.R., Ackerman, S., Mei, L., Xiong, W.C. J. Biol. Chem. (2006)
- Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1. Moore, S.W., Correia, J.P., Lai Wing Sun, K., Pool, M., Fournier, A.E., Kennedy, T.E. Development (2008)
- Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. Qin, S., Yu, L., Gao, Y., Zhou, R., Zhang, C. Mol. Cell. Neurosci. (2007)
- The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Van Raay, T.J., Foskett, S.M., Connors, T.D., Klinger, K.W., Landes, G.M., Burn, T.C. Genomics (1997)
- FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. Li, W., Aurandt, J., Jürgense, C., Rao, Y., Guan, K.L. J. Cell. Sci. (2006)
- Cellular expression of a leech netrin suggests roles in the formation of longitudinal nerve tracts and in regional innervation of peripheral targets. Gan, W.B., Wong, V.Y., Phillips, A., Ma, C., Gershon, T.R., Macagno, E.R. J. Neurobiol. (1999)