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Gene Review:

BMP7 - bone morphogenetic protein 7

Sus scrofa

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Disease relevance of Bmp7

Poly-L-lactic acid/hydroxyapatite composite scaffolds were differentially seeded with fibroblasts transduced with an adenovirus expressing bone morphogenetic protein 7 (BMP-7) in the ceramic phase and fully differentiated chondrocytes in the polymeric phase [1].

High impact information on Bmp7

Bone morphogenetic protein-7 (BMP 7) induces cementogenesis in periodontitis-associated periodontal ligament (PDL) defects [2].
Scaffolds were then seeded with bone morphogenetic protein-7 (BMP-7) transduced fibroblasts and implanted subcutaneously to evaluate biological properties and to demonstrate tissue in-growth [3].
Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7) [4].
A significant (P<.05) dose-dependent stimulation of proteoglycan synthesis was found with platelet-derived growth factor AB (PDGF-[AB]), transforming growth factor-beta1 and bone morphogenetic protein-7 (osteogenic protein-I) [5].

References

Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffolds. Schek, R.M., Taboas, J.M., Segvich, S.J., Hollister, S.J., Krebsbach, P.H. Tissue engineering. (2004) [Pubmed]
RhBMP-7 improves survival and eruption in a growing tooth avulsion trauma model. Springer, I.N., Açil, Y., Spies, C., Jepsen, S., Warnke, P.H., Bolte, H., Kuchenbecker, S., Russo, P.A., Wiltfang, J., Terheyden, H. Bone (2005) [Pubmed]
Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Williams, J.M., Adewunmi, A., Schek, R.M., Flanagan, C.L., Krebsbach, P.H., Feinberg, S.E., Hollister, S.J., Das, S. Biomaterials (2005) [Pubmed]
Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1 (bone morphogenetic protein-7). Lietman, S.A., Yanagishita, M., Sampath, T.K., Reddi, A.H. The Journal of bone and joint surgery. American volume. (1997) [Pubmed]
Effects of selected growth factors on porcine meniscus in chemically defined medium. Lietman, S.A., Hobbs, W., Inoue, N., Reddi, A.H. Orthopedics. (2003) [Pubmed]

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