The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

TGFB1  -  transforming growth factor, beta 1

Sus scrofa

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TGFB1


High impact information on TGFB1


Chemical compound and disease context of TGFB1


Biological context of TGFB1


Anatomical context of TGFB1


Associations of TGFB1 with chemical compounds


Physical interactions of TGFB1


Regulatory relationships of TGFB1


Other interactions of TGFB1


Analytical, diagnostic and therapeutic context of TGFB1


  1. Promoter sequences involved in transforming growth factor beta1 gene induction in HaCaT keratinocytes after gamma irradiation. Gault, N., Vozenin-Brotons, M.C., Calenda, A., Lefaix, J.L., Martin, M.T. Radiat. Res. (2002) [Pubmed]
  2. Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation. Kitani, A., Fuss, I.J., Nakamura, K., Schwartz, O.M., Usui, T., Strober, W. J. Exp. Med. (2000) [Pubmed]
  3. Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1. Moritani, M., Yoshimoto, K., Wong, S.F., Tanaka, C., Yamaoka, T., Sano, T., Komagata, Y., Miyazaki, J., Kikutani, H., Itakura, M. J. Clin. Invest. (1998) [Pubmed]
  4. T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta. Wrann, M., Bodmer, S., de Martin, R., Siepl, C., Hofer-Warbinek, R., Frei, K., Hofer, E., Fontana, A. EMBO J. (1987) [Pubmed]
  5. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Nabel, E.G., Shum, L., Pompili, V.J., Yang, Z.Y., San, H., Shu, H.B., Liptay, S., Gold, L., Gordon, D., Derynck, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta. Mason, A.J., Hayflick, J.S., Ling, N., Esch, F., Ueno, N., Ying, S.Y., Guillemin, R., Niall, H., Seeburg, P.H. Nature (1985) [Pubmed]
  7. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. Kolm-Litty, V., Sauer, U., Nerlich, A., Lehmann, R., Schleicher, E.D. J. Clin. Invest. (1998) [Pubmed]
  8. Transforming growth factor beta regulation of migration in wounded rat intestinal epithelial monolayers. Ciacci, C., Lind, S.E., Podolsky, D.K. Gastroenterology (1993) [Pubmed]
  9. The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells. Sato, Y., Okada, F., Abe, M., Seguchi, T., Kuwano, M., Sato, S., Furuya, A., Hanai, N., Tamaoki, T. J. Cell Biol. (1993) [Pubmed]
  10. Captopril reverses high-glucose-induced growth effects on LLC-PK1 cells partly by decreasing transforming growth factor-beta receptor protein expressions. Guh, J.Y., Yang, M.L., Yang, Y.L., Chang, C.C., Chuang, L.Y. J. Am. Soc. Nephrol. (1996) [Pubmed]
  11. Normoxic wound fluid contains high levels of vascular endothelial growth factor. Howdieshell, T.R., Riegner, C., Gupta, V., Callaway, D., Grembowicz, K., Sathyanarayana, n.u.l.l., McNeil, P.L. Ann. Surg. (1998) [Pubmed]
  12. Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure. Miyazaki, T., Ise, M., Hirata, M., Endo, K., Ito, Y., Seo, H., Niwa, T. Kidney Int. Suppl. (1997) [Pubmed]
  13. cDNA cloning of porcine transforming growth factor-beta 1 mRNAs. Evidence for alternate splicing and polyadenylation. Kondaiah, P., Van Obberghen-Schilling, E., Ludwig, R.L., Dhar, R., Sporn, M.B., Roberts, A.B. J. Biol. Chem. (1988) [Pubmed]
  14. BF, HP, DQB and DRB are associated with haemolytic complement activity, acute phase protein reaction and antibody response in the pig. Wimmers, K., Schellander, K., Ponsuksili, S. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  15. Nucleotide sequence of chicken transforming growth factor-beta 1 (TGF-beta 1). Jakowlew, S.B., Dillard, P.J., Sporn, M.B., Roberts, A.B. Nucleic Acids Res. (1988) [Pubmed]
  16. Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. Jhappan, C., Geiser, A.G., Kordon, E.C., Bagheri, D., Hennighausen, L., Roberts, A.B., Smith, G.H., Merlino, G. EMBO J. (1993) [Pubmed]
  17. Growth regulation of skin cells by epidermal cell-derived factors: implications for wound healing. Eisinger, M., Sadan, S., Silver, I.A., Flick, R.B. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  18. Synthesis of transforming growth factor-beta 1 by megakaryocytes and its localization to megakaryocyte and platelet alpha-granules. Fava, R.A., Casey, T.T., Wilcox, J., Pelton, R.W., Moses, H.L., Nanney, L.B. Blood (1990) [Pubmed]
  19. Drug resistance and gene amplification potential regulated by transforming growth factor beta 1 gene expression. Huang, A., Jin, H., Wright, J.A. Cancer Res. (1995) [Pubmed]
  20. A comparison of the effect of transforming growth factor beta 1 on pyrophosphate elaboration from various articular tissues. Rosenthal, A.K., McCarty, B.A., Cheung, H.S., Ryan, L.M. Arthritis Rheum. (1993) [Pubmed]
  21. Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. Kraus, V.B., Huebner, J.L., Stabler, T., Flahiff, C.M., Setton, L.A., Fink, C., Vilim, V., Clark, A.G. Arthritis Rheum. (2004) [Pubmed]
  22. Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. Sheppard, D., Cohen, D.S., Wang, A., Busk, M. J. Biol. Chem. (1992) [Pubmed]
  23. Novel 150- and 180-kDa glycoproteins that bind transforming growth factor (TGF)-beta 1 but not TGF-beta 2 are present in several cell lines. MacKay, K., Danielpour, D. J. Biol. Chem. (1991) [Pubmed]
  24. Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. Yamashita, H., Ichijo, H., Grimsby, S., Morén, A., ten Dijke, P., Miyazono, K. J. Biol. Chem. (1994) [Pubmed]
  25. Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury. Sinha, S., Heagerty, A.M., Shuttleworth, C.A., Kielty, C.M. Cardiovasc. Res. (2002) [Pubmed]
  26. Transforming growth factor-beta is a potent inhibitor of basal and stimulated relaxin release by porcine luteal cells maintained in monolayer culture. Taylor, M.J., Clark, C.L. J. Endocrinol. (1992) [Pubmed]
  27. Cloning and expression of guinea pig TIMP-2. Expression in normal and hyperoxic lung injury. Meléndez, J., Maldonado, V., Bingle, C.D., Selman, M., Pardo, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  28. Expression of cartilage intermediate layer protein/nucleotide pyrophosphohydrolase parallels the production of extracellular inorganic pyrophosphate in response to growth factors and with aging. Hirose, J., Masuda, I., Ryan, L.M. Arthritis Rheum. (2000) [Pubmed]
  29. Recovery from heat shock injury by activation of Na+-glucose cotransporter in renal epithelial cells. Ikari, A., Nakano, M., Ishibashi, M., Kawano, K., Suketa, Y., Harada, H., Takagi, K. Biochim. Biophys. Acta (2003) [Pubmed]
  30. Influence of transforming growth factor beta1 (TGF-beta1) on the behaviour of porcine thyroid epithelial cells in primary culture through thrombospondin-1 synthesis. Claisse, D., Martiny, I., Chaqour, B., Wegrowski, Y., Petitfrere, E., Schneider, C., Haye, B., Bellon, G. J. Cell. Sci. (1999) [Pubmed]
  31. Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Díaz, I., Darwich, L., Pappaterra, G., Pujols, J., Mateu, E. Virology (2006) [Pubmed]
  32. Effect of Vacuum Assisted Closure Therapy on early systemic cytokine levels in a swine model. Kilpadi, D.V., Bower, C.E., Reade, C.C., Robinson, P.J., Sun, Y.S., Zeri, R., Nifong, L.W., Wooden, W.A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2006) [Pubmed]
  33. TGF-beta 1 causes increased endothelial ICAM-1 expression and lung injury. Suzuki, Y., Tanigaki, T., Heimer, D., Wang, W., Ross, W.G., Murphy, G.A., Sakai, A., Sussman, H.H., Vu, T.H., Raffin, T.A. J. Appl. Physiol. (1994) [Pubmed]
  34. Temporal and spatial expression of connective tissue growth factor (CCN2; CTGF) and transforming growth factor beta type 1 (TGF-beta1) at the utero-placental interface during early pregnancy in the pig. Moussad, E.E., Rageh, M.A., Wilson, A.K., Geisert, R.D., Brigstock, D.R. MP, Mol. Pathol. (2002) [Pubmed]
  35. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin. Ling, N., Ying, S.Y., Ueno, N., Shimasaki, S., Esch, F., Hotta, M., Guillemin, R. Nature (1986) [Pubmed]
  36. Contribution of sinusoidal endothelial liver cells to liver fibrosis: expression of transforming growth factor-beta 1 receptors and modulation of plasmin-generating enzymes by transforming growth factor-beta 1. Rieder, H., Armbrust, T., Meyer zum Büschenfelde, K.H., Ramadori, G. Hepatology (1993) [Pubmed]
  37. Purification of transforming growth factor-beta 1 binding proteins from porcine uterus membranes. Ichijo, H., Rönnstrand, L., Miyagawa, K., Ohashi, H., Heldin, C.H., Miyazono, K. J. Biol. Chem. (1991) [Pubmed]
WikiGenes - Universities