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Gene Review

OAS2  -  2'-5'-oligoadenylate synthetase 2, 69/71kDa

Homo sapiens

Synonyms: (2-5')oligo(A) synthase 2, 2'-5'-oligoadenylate synthase 2, 2-5A synthase 2
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Disease relevance of OAS2

  • Biochemical analyses using recombinant proteins produced in Escherichia coli showed that all the novel mouse 2-5OAS molecules have double-stranded RNA (dsRNA) binding ability, but they do not have 2-5OAS activity except for the OAS2 and OAS3 mouse homologs [1].

High impact information on OAS2

  • Only one gene, OAS2, was differentially expressed by these cell lines, and this was confirmed by quantitative PCR [2].
  • OAS1 is the small form and OAS2 is the medium form of the human interferon-induced 2'-5' oligoadenylate synthetases [3].
  • DON also impaired induction of two type 1 IFN-dependent antiviral genes, double-stranded RNA activated protein kinase R (PKR) and oligoadenylate synthase 2 (OAS2) [4].
  • We characterize the anti-viral responses of synthetic siRNA and in vitro-transcribed siRNA by measuring the mRNA levels of IFN-beta and OAS2 in HeLa cells [5].
  • In mice, however, OAS genes corresponding to human OAS2 and OAS3 have not been identified [1].

Biological context of OAS2


  1. Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. Kakuta, S., Shibata, S., Iwakura, Y. J. Interferon Cytokine Res. (2002) [Pubmed]
  2. Does HLA-B27 influence the monocyte inflammatory response to lipopolysaccharide? Goodall, J.C., Ellis, L., Yeo, G.S., Gaston, J.S. Rheumatology (Oxford, England) (2007) [Pubmed]
  3. Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions. Hartmann, R., Walko, G., Justesen, J. FEBS Lett. (2001) [Pubmed]
  4. Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. Li, M., Harkema, J.R., Cuff, C.F., Pestka, J.J. Toxicol. Sci. (2007) [Pubmed]
  5. No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA. Dahlgren, C., Wahlestedt, C., Thonberg, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. Hovnanian, A., Rebouillat, D., Mattei, M.G., Levy, E.R., Marié, I., Monaco, A.P., Hovanessian, A.G. Genomics (1998) [Pubmed]
  7. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? Tessier, M.C., Qu, H.Q., Fréchette, R., Bacot, F., Grabs, R., Taback, S.P., Lawson, M.L., Kirsch, S.E., Hudson, T.J., Polychronakos, C. J. Med. Genet. (2006) [Pubmed]
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