The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

OAS3  -  2'-5'-oligoadenylate synthetase 3, 100kDa

Homo sapiens

Synonyms: (2-5')oligo(A) synthase 3, 2'-5'-oligoadenylate synthase 3, 2-5A synthase 3, P/OKcl.4, p100, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of OAS3

  • Biochemical analyses using recombinant proteins produced in Escherichia coli showed that all the novel mouse 2-5OAS molecules have double-stranded RNA (dsRNA) binding ability, but they do not have 2-5OAS activity except for the OAS2 and OAS3 mouse homologs [1].
  • Activation of the noncanonical NF-kappaB signaling pathway involved in the proteolytic processing of NF-kappaB p100 to p52 is tightly regulated, and overproduction of p52 leads to lymphocyte hyperplasia and transformation [2].
  • These results show that increased p100/p52 disrupts normal ductal development and provides insight into the mechanism by which this may contribute to human breast cancer [3].
 

High impact information on OAS3

  • Our studies demonstrate a different mechanism of p100 processing and also present evidence showing that the proteasome modulates the action of transcription factors at promoter regions through endoproteolysis [4].
  • Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation [2].
  • After multiple pregnancies the p100 transgenics exhibited a ductal thickening accompanied by small hyperplastic foci [3].
  • In tumors from mice expressing the polyoma middle T oncoprotein (PyVT) in the mammary gland, increased levels of p100/p52 were present at the time of tumor development [3].
  • Indeed, further in vitro experiments established that s-rIkappaB DC undergo efficient maturation upon prolonged contact with activated T cells via the alternative pathway of NF-kappaB activation triggered at least partly by lymphotoxin beta receptor ligation and involving processing of p100/RelB complexes [5].
 

Biological context of OAS3

  • The promoter region of the p100 gene is composed of multiple features conferring direct inducibility not only by IFNs but also by TNF and all-trans retinoic acid [6].
  • An OAS3 gene was not found in either the cattle or the pig genome [7].
  • Additionally, induction of p100 phosphorylation can be blocked by a protein synthesis inhibitor, suggesting the requirement of de novo protein synthesis [8].
  • The pattern reversal visual evoked potentials elicited to 50' checks with three reversals per second viewed with both eyes were analyzed for n80-p100 amplitude, p100 latency, and breadth of waveform [9].
 

Associations of OAS3 with chemical compounds

  • Mutation of either serine 866 or serine 870 abolishes the beta-TrCP recruitment and ubiquitination of p100 [8].
 

Other interactions of OAS3

  • In mice, however, OAS genes corresponding to human OAS2 and OAS3 have not been identified [1].
  • In contrast, the induction of the p100 promoter by dsRNA is indirect and requires IFN type I production [6].
 

Analytical, diagnostic and therapeutic context of OAS3

References

  1. Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. Kakuta, S., Shibata, S., Iwakura, Y. J. Interferon Cytokine Res. (2002) [Pubmed]
  2. Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Nadiminty, N., Lou, W., Lee, S.O., Lin, X., Trump, D.L., Gao, A.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. A Transgenic Model Reveals Important Roles for the NF-{kappa}B Alternative Pathway (p100/p52) in Mammary Development and Links to Tumorigenesis. Connelly, L., Robinson-Benion, C., Chont, M., Saint-Jean, L., Li, H., Polosukhin, V.V., Blackwell, T.S., Yull, F.E. J. Biol. Chem. (2007) [Pubmed]
  4. Endoproteolytic processing of C-terminally truncated NF-{kappa}B2 precursors at {kappa}B-containing promoters. Qing, G., Qu, Z., Xiao, G. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  5. An Alternative Pathway of NF-{kappa}B Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated I{kappa}B{alpha}. Moore, F., Buonocore, S., Aksoy, E., Ouled-Haddou, N., Goriely, S., Lazarova, E., Paulart, F., Heirman, C., Vaeremans, E., Thielemans, K., Goldman, M., Flamand, V. J. Immunol. (2007) [Pubmed]
  6. Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase. Rebouillat, D., Hovnanian, A., David, G., Hovanessian, A.G., Williams, B.R. Genomics (2000) [Pubmed]
  7. The Mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous oas1 genes in rodentia and artiodactyla. Perelygin, A.A., Zharkikh, A.A., Scherbik, S.V., Brinton, M.A. J. Mol. Evol. (2006) [Pubmed]
  8. beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Liang, C., Zhang, M., Sun, S.C. Cell. Signal. (2006) [Pubmed]
  9. Prevalence of abnormal pattern reversal visual evoked potentials in craniosynostosis. Thompson, D.A., Liasis, A., Hardy, S., Hagan, R., Hayward, R.D., Evans, R.D., Nischal, K.K. Plast. Reconstr. Surg. (2006) [Pubmed]
  10. The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains. Rebouillat, D., Hovnanian, A., Marié, I., Hovanessian, A.G. J. Biol. Chem. (1999) [Pubmed]
 
WikiGenes - Universities