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Gene Review

pax3-a  -  paired box 3

Xenopus laevis

Synonyms: pax-3, pax3, pax3a, xPax3-A, xpax3
 
 
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High impact information on Pax3

  • The induction of neural crest differentiation by Pax3 and Zic1 requires Wnt signaling [1].
  • Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm [1].
  • These fibres probably derive from an outer cell layer expressing the myogenic determination genes XMyf5, XMyoD and Pax3 in a pattern reminiscent of amniote dermomyotome [2].
  • Chick posterior non-axial mesoderm also induces Pax-3, provided that the animal caps are neuralized by treatment with noggin [3].
  • Third, in a heterospecies explant recombinant assay with Xenopus animal caps (ectoderm) as a responding tissue, late, but not early, Hensen's node induces Pax-3 expression [3].
 

Anatomical context of Pax3

  • Thus, WNT and FGF8 signals act in parallel at the neural border and converge on Pax3 activity during neural crest induction [4].
  • Here, we show that the cooperative function of Pax3 and Zic1 determines the neural crest fate in the amphibian ectoderm [1].
  • In this report we use recombinant limbs to analyze pattering of the Pax3 expressing limb muscle cell lineage in the early stages of limb development [5].
  • Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm [3].
  • Second, Hensen's node and posterior non-axial mesoderm which underlies the neural plate induce Pax-3 expression when combined with presumptive anterior neural plate explants [3].
 

Associations of Pax3 with chemical compounds

 

Regulatory relationships of Pax3

  • Msx1 induces Pax3 and ZicR1 cell autonomously, in turn, Pax3 combined with ZicR1 activates Slug in a WNT-dependent manner [4].
 

Other interactions of Pax3

  • To understand how these signals are integrated, we have analyzed the role of the transcription factors Msx1 and Pax3 [4].

References

  1. Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm. Sato, T., Sasai, N., Sasai, Y. Development (2005) [Pubmed]
  2. Hedgehog regulation of superficial slow muscle fibres in Xenopus and the evolution of tetrapod trunk myogenesis. Grimaldi, A., Tettamanti, G., Martin, B.L., Gaffield, W., Pownall, M.E., Hughes, S.M. Development (2004) [Pubmed]
  3. Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm. Bang, A.G., Papalopulu, N., Kintner, C., Goulding, M.D. Development (1997) [Pubmed]
  4. Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction. Monsoro-Burq, A.H., Wang, E., Harland, R. Dev. Cell (2005) [Pubmed]
  5. The recombinant limb as a model for the study of limb patterning, and its application to muscle development. Fernandez-Teran, M., Piedra, M.E., Ros, M.A., Fallon, J.F. Cell Tissue Res. (1999) [Pubmed]
 
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