High impact information on Pax3

• The induction of neural crest differentiation by Pax3 and Zic1 requires Wnt signaling [1].
• Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm [1].
• These fibres probably derive from an outer cell layer expressing the myogenic determination genes XMyf5, XMyoD and Pax3 in a pattern reminiscent of amniote dermomyotome [2].
• Chick posterior non-axial mesoderm also induces Pax-3, provided that the animal caps are neuralized by treatment with noggin [3].
• Third, in a heterospecies explant recombinant assay with Xenopus animal caps (ectoderm) as a responding tissue, late, but not early, Hensen's node induces Pax-3 expression [3].

Anatomical context of Pax3

• Thus, WNT and FGF8 signals act in parallel at the neural border and converge on Pax3 activity during neural crest induction [4].
• Here, we show that the cooperative function of Pax3 and Zic1 determines the neural crest fate in the amphibian ectoderm [1].
• In this report we use recombinant limbs to analyze pattering of the Pax3 expressing limb muscle cell lineage in the early stages of limb development [5].
• Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm [3].
• Second, Hensen's node and posterior non-axial mesoderm which underlies the neural plate induce Pax-3 expression when combined with presumptive anterior neural plate explants [3].

Associations of Pax3 with chemical compounds

• Finally we show that the putative posteriorizing factors, retinoic acid and bFGF, induce Pax-3 in neuralized animal caps [3].

Regulatory relationships of Pax3

• Msx1 induces Pax3 and ZicR1 cell autonomously, in turn, Pax3 combined with ZicR1 activates Slug in a WNT-dependent manner [4].

Other interactions of Pax3

• To understand how these signals are integrated, we have analyzed the role of the transcription factors Msx1 and Pax3 [4].

References