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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Coq2  -  coenzyme Q2 4-hydroxybenzoate...

Rattus norvegicus

Synonyms: 4-hydroxybenzoate polyprenyltransferase, mitochondrial, PHB:polyprenyltransferase, Para-hydroxybenzoate--polyprenyltransferase
 
 
 
 
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High impact information on Coq2

  • Polyprenyl 4-hydroxybenzoate transferase (Coq2p) plays a central role in ubiquinone biosynthesis [1].
  • With our improved method, we were able to measure Coq2p activity with much greater sensitivity in both fresh and frozen/thawed mitochondria and in crude homogenates obtained from cultured cells [1].
 

Associations of Coq2 with chemical compounds

  • Our method will simplify evaluation of Coq2p activity in scarce biological materials, such as cells obtained from human tissue biopsies, and thus it will facilitate the biochemical characterization of ubiquinone deficiencies [1].

References

  1. Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate. Burón, M.I., Hermán, M.D., Alcaín, F.J., Villalba, J.M. Anal. Biochem. (2006) [Pubmed]
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