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Gene Review

COQ2  -  4-hydroxybenzoate octaprenyltransferase

Saccharomyces cerevisiae S288c

Synonyms: 4-hydroxybenzoate polyprenyltransferase, mitochondrial, N3419, PHB:polyprenyltransferase, Para-hydroxybenzoate--polyprenyltransferase, YNR041C
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Disease relevance of COQ2

  • A previously sequenced long open reading frame that encodes the C-terminal portion of the E. coli ubiA product (4-hydroxybenzoate polyprenyltransferase, HPTase) shows a high degree of sequence identity with the corresponding segment of yeast HPTase (the COQ2 gene product) [1].

High impact information on COQ2


Biological context of COQ2

  • The rice genome contains three PPT candidates that share significant similarity with the yeast PPT (COQ2 gene), and the rice gene showing the highest similarity to COQ2 was isolated by reverse transcription-PCR and designated OsPPT1a [5].
  • This strongly supports the idea that COQ2 catalyzes the same enzymatic reaction with UbiA and the substrate specificity of COQ2 is broad [6].
  • Engineering of ubiquinone biosynthesis using the yeast coq2 gene confers oxidative stress tolerance in transgenic tobacco [7].


  1. The 92-min region of the Escherichia coli chromosome: location and cloning of the ubiA and alr genes. Lilley, P.E., Stamford, N.P., Vasudevan, S.G., Dixon, N.E. Gene (1993) [Pubmed]
  2. Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis. Yazaki, K., Kunihisa, M., Fujisaki, T., Sato, F. J. Biol. Chem. (2002) [Pubmed]
  3. COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase. Ashby, M.N., Kutsunai, S.Y., Ackerman, S., Tzagoloff, A., Edwards, P.A. J. Biol. Chem. (1992) [Pubmed]
  4. Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase. Ashby, M.N., Edwards, P.A. J. Biol. Chem. (1990) [Pubmed]
  5. Functional characterization of OsPPT1, which encodes p-hydroxybenzoate polyprenyltransferase involved in ubiquinone biosynthesis in Oryza sativa. Ohara, K., Yamamoto, K., Hamamoto, M., Sasaki, K., Yazaki, K. Plant Cell Physiol. (2006) [Pubmed]
  6. Evidence that Escherichia coli ubiA product is a functional homolog of yeast COQ2, and the regulation of ubiA gene expression. Suzuki, K., Ueda, M., Yuasa, M., Nakagawa, T., Kawamukai, M., Matsuda, H. Biosci. Biotechnol. Biochem. (1994) [Pubmed]
  7. Engineering of ubiquinone biosynthesis using the yeast coq2 gene confers oxidative stress tolerance in transgenic tobacco. Ohara, K., Kokado, Y., Yamamoto, H., Sato, F., Yazaki, K. Plant J. (2004) [Pubmed]
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