The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FPGS  -  folylpolyglutamate synthase

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on FPGS

  • Based on their ratios of Vmax to Km, AM is a better substrate than is MTX for the beef liver FPGS [1].
  • Folinic acid, often used as the rescue agent in high-dose MTX therapy, has a low Km with mammalian FPGS (7 microM) [1].
  • The antifolate drugs methotrexate (MTX) and aminopterin (AM) have been tested as substrates for folylpolyglutamate synthetase (FPGS) partially purified from beef liver [1].
  • The activities of folate and antifolate substrates also have been determined with rat liver FPGS [1].


  1. Folate analogues as substrates of mammalian folylpolyglutamate synthetase. Schoo, M.M., Pristupa, Z.B., Vickers, P.J., Scrimgeour, K.G. Cancer Res. (1985) [Pubmed]
WikiGenes - Universities