Gene Review:
FPGS - folylpolyglutamate synthase
Bos taurus
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High impact information on FPGS
- Based on their ratios of Vmax to Km, AM is a better substrate than is MTX for the beef liver FPGS [1].
- Folinic acid, often used as the rescue agent in high-dose MTX therapy, has a low Km with mammalian FPGS (7 microM) [1].
- The antifolate drugs methotrexate (MTX) and aminopterin (AM) have been tested as substrates for folylpolyglutamate synthetase (FPGS) partially purified from beef liver [1].
- The activities of folate and antifolate substrates also have been determined with rat liver FPGS [1].
References
- Folate analogues as substrates of mammalian folylpolyglutamate synthetase. Schoo, M.M., Pristupa, Z.B., Vickers, P.J., Scrimgeour, K.G. Cancer Res. (1985) [Pubmed]
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