Chemical Compound Review:
AC1N9ZJC (2S)-2-[[(1R)-4-[(2,4- diamino-2,3...
Synonyms:
- Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia. Winick, N.J., Bowman, W.P., Kamen, B.A., Roach, E.S., Rollins, N., Jacaruso, D., Buchanan, G.R. J. Natl. Cancer Inst. (1992)
- Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates. Chung, K.N., Saikawa, Y., Paik, T.H., Dixon, K.H., Mulligan, T., Cowan, K.H., Elwood, P.C. J. Clin. Invest. (1993)
- Rapid development of resistance to antifolates in vitro: possible clinical implication. Sobrero, A., Aschele, C., Rosso, R., Nicolin, A., Bertino, J.R. J. Natl. Cancer Inst. (1991)
- Decreased rejection and improved survival of first and second marrow transplants for severe aplastic anemia (a 26-year retrospective analysis). Stucki, A., Leisenring, W., Sandmaier, B.M., Sanders, J., Anasetti, C., Storb, R. Blood (1998)
- The AIMS2-SF: a short form of the Arthritis Impact Measurement Scales 2. French Quality of Life in Rheumatology Group. Guillemin, F., Coste, J., Pouchot, J., Ghézail, M., Bregeon, C., Sany, J. Arthritis Rheum. (1997)
- FK506 ameliorates spontaneous locomotor activity in collagen-induced arthritis: implication of distinct effect from suppression of inflammation. Sasakawa, T., Sasakawa, Y., Ohkubo, Y., Mutoh, S. Int. Immunopharmacol. (2005)
- Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus. Trask, B.J., Hamlin, J.L. Genes Dev. (1989)
- A novel intermediate on the import pathway of cytochrome b2 into mitochondria: evidence for conservative sorting. Gruhler, A., Ono, H., Guiard, B., Neupert, W., Stuart, R.A. EMBO J. (1995)
- Cloning and expression of the chromosomal immune interferon gene of the rat. Dijkema, R., van der Meide, P.H., Pouwels, P.H., Caspers, M., Dubbeld, M., Schellekens, H. EMBO J. (1985)
- Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. Gourley, D.G., Schüttelkopf, A.W., Leonard, G.A., Luba, J., Hardy, L.W., Beverley, S.M., Hunter, W.N. Nat. Struct. Biol. (2001)
- Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Li, W., Fan, J., Hochhauser, D., Banerjee, D., Zielinski, Z., Almasan, A., Yin, Y., Kelly, R., Wahl, G.M., Bertino, J.R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Allogeneic marrow transplantation during untreated first relapse of acute myeloid leukemia. Clift, R.A., Buckner, C.D., Appelbaum, F.R., Schoch, G., Petersen, F.B., Bensinger, W.I., Sanders, J., Sullivan, K.M., Storb, R., Singer, J. J. Clin. Oncol. (1992)
- Improvement in outcome for children receiving allogeneic bone marrow transplantation in first remission of acute myeloid leukemia: a report from the Groupe d'Etude des Greffes de Moelle Osseuse. Michel, G., Gluckman, E., Blaise, D., Esperou-Bourdeau, H., Vernant, J.P., Kuentz, M., Bordigoni, P., Milpied, N., Rubie, H., Thuret, I. J. Clin. Oncol. (1992)
- Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Hooijberg, J.H., Broxterman, H.J., Kool, M., Assaraf, Y.G., Peters, G.J., Noordhuis, P., Scheper, R.J., Borst, P., Pinedo, H.M., Jansen, G. Cancer Res. (1999)
- Rapid responses to anakinra in patients with refractory adult-onset Still's disease. Fitzgerald, A.A., Leclercq, S.A., Yan, A., Homik, J.E., Dinarello, C.A. Arthritis Rheum. (2005)
- Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients. Freilich, R.J., Delattre, J.Y., Monjour, A., DeAngelis, L.M. Neurology (1996)
- Quantitative correlation of homogeneously stained regions on chromosome 10 with dihydrofolate reductase enzyme in human cells. Wolman, S.R., Craven, M.L., Grill, S.P., Domin, B.A., Cheng, Y.C. Proc. Natl. Acad. Sci. U.S.A. (1983)
- Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea. Snapka, R.M., Varshavsky, A. Proc. Natl. Acad. Sci. U.S.A. (1983)
- Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs. Eastman, H.B., Swick, A.G., Schmitt, M.C., Azizkhan, J.C. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Chromosome instability associated with human alphoid DNA transfected into the Chinese hamster genome. Heartlein, M.W., Knoll, J.H., Latt, S.A. Mol. Cell. Biol. (1988)
- Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization. McGuire, J.J., Bergoltz, V.V., Heitzman, K.J., Haile, W.H., Russell, C.A., Bolanowska, W.E., Kotake, Y., Haneda, T., Nomura, H. Cancer Res. (1994)
- Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells. Longo, G.S., Gorlick, R., Tong, W.P., Ercikan, E., Bertino, J.R. Blood (1997)
- Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Barker, J.N., Davies, S.M., DeFor, T., Ramsay, N.K., Weisdorf, D.J., Wagner, J.E. Blood (2001)
- Importance of effective central nervous system therapy in isolated bone marrow relapse of childhood acute lymphoblastic leukemia. BFM (Berlin-Frankfurt-Münster) Relapse Study Group. Bührer, C., Hartmann, R., Fengler, R., Schober, S., Arlt, I., Loewke, M., Henze, G. Blood (1994)
- Phase I/II trial of recombinant human granulocyte-macrophage colony-stimulating factor following allogeneic bone marrow transplantation. Nemunaitis, J., Buckner, C.D., Appelbaum, F.R., Higano, C.S., Mori, M., Bianco, J., Epstein, C., Lipani, J., Hansen, J., Storb, R. Blood (1991)
- Depletion of donor lymphocytes by counterflow centrifugation successfully prevents acute graft-versus-host disease in matched allogeneic marrow transplantation. de Witte, T., Hoogenhout, J., de Pauw, B., Holdrinet, R., Janssen, J., Wessels, J., van Daal, W., Hustinx, T., Haanen, C. Blood (1986)
- Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection. Hale, G., Zhang, M.J., Bunjes, D., Prentice, H.G., Spence, D., Horowitz, M.M., Barrett, A.J., Waldmann, H. Blood (1998)
- Improved outcome in adult B-cell acute lymphoblastic leukemia. Hoelzer, D., Ludwig, W.D., Thiel, E., Gassmann, W., Löffler, H., Fonatsch, C., Rieder, H., Heil, G., Heinze, B., Arnold, R., Hossfeld, D., Büchner, T., Koch, P., Freund, M., Hiddemann, W., Maschmeyer, G., Heyll, A., Aul, C., Faak, T., Kuse, R., Ittel, T.H., Gramatzki, M., Diedrich, H., Kolbe, K., Fuhr, H.G., Fischer, K., Schadeck-Gressel, C., Weiss, A., Strohscheer, I., Metzner, B., Fabry, U., Gökbuget, N., Völkers, B., Messerer, D., Uberla, K. Blood (1996)
- Intensive, very short-term chemotherapy for advanced Burkitt's lymphoma in children. Spreafico, F., Massimino, M., Luksch, R., Casanova, M., Cefalo, G.S., Collini, P., Ferrari, A., Polastri, D., Terenziani, M., Gasparini, M., Fossati-Bellani, F. J. Clin. Oncol. (2002)
- Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors. Jansen, G., Schornagel, J.H., Westerhof, G.R., Rijksen, G., Newell, D.R., Jackman, A.L. Cancer Res. (1990)
- Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines. McGuire, J.J., Russell, C.A., Balinska, M. J. Biol. Chem. (2000)
- Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligand. Lee, C.K., Lee, E.Y., Chung, S.M., Mun, S.H., Yoo, B., Moon, H.B. Arthritis Rheum. (2004)
- Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis. Ifergan, I., Shafran, A., Jansen, G., Hooijberg, J.H., Scheffer, G.L., Assaraf, Y.G. J. Biol. Chem. (2004)
- Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding. Bonifaci, N., Sitia, R., Rubartelli, A. AIDS (1995)
- Permanent exposure of mucin-secreting HT-29 cells to benzyl-N-acetyl-alpha-D-galactosaminide induces abnormal O-glycosylation of mucins and inhibits constitutive and stimulated MUC5AC secretion. Hennebicq-Reig, S., Lesuffleur, T., Capon, C., De Bolos, C., Kim, I., Moreau, O., Richet, C., Hémon, B., Recchi, M.A., Maës, E., Aubert, J.P., Real, F.X., Zweibaum, A., Delannoy, P., Degand, P., Huet, G. Biochem. J. (1998)
- Combination intrathecal therapy for meningeal leukemia: two versus three drugs. Sullivan, M.P., Moon, T.E., Trueworthy, R., Vietti, T.J., Humphrey, G.B., Komp, D. Blood (1977)
- Equivalence of intrathecal chemotherapy and radiotherapy as central nervous system prophylaxis in children with acute lymphatic leukemia: a pediatric oncology group study. Sullivan, M.P., Chen, T., Dyment, P.G., Hvizdala, E., Steuber, C.P. Blood (1982)
- Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Reiter, A., Schrappe, M., Ludwig, W.D., Hiddemann, W., Sauter, S., Henze, G., Zimmermann, M., Lampert, F., Havers, W., Niethammer, D. Blood (1994)