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Gene Review

MET7  -  tetrahydrofolate synthase

Saccharomyces cerevisiae S288c

Synonyms: FPGS, Folylpoly-gamma-glutamate synthetase, Folylpolyglutamate synthase, MET23, O5248, ...
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High impact information on MET7

  • Thus, the combination of FPGS with these folate-mediated reactions can supply each compartment with the polyglutamylated folate coenzymes required for the reactions of C1 metabolism [1].
  • The function of each enzyme was demonstrated by complementation of yeast mutants deficient in DHFS or FPGS activity, and by measuring in vitro glutamate incorporation into dihydrofolate or tetrahydrofolate [1].
  • In organisms that synthesize tetrahydrofolate de novo, dihydrofolate synthetase (DHFS) and folylpolyglutamate synthetase (FPGS) catalyze the attachment of glutamate residues to the folate molecule [1].
  • In contrast, FPGS is present as distinct isoforms in the mitochondria, the cytosol, and the chloroplast [1].
  • Immunological crossreactivity of eukaryotic C1-tetrahydrofolate synthase and prokaryotic 10-formyltetrahydrofolate synthetase [2].

Biological context of MET7

  • We also mapped the DFR1 gene to a position 1.4 cM proximal to the MET7 locus on chromosome XV [3].
  • The met7 mutant becomes petite under normal growth conditions but can be maintained with a grande phenotype if the strain is tup and all media are supplemented with dTMP [4].
  • O5248 is a probable folypolyglutamate synthetase, having two structural homologs already sequenced in the yeast genome [5].

Associations of MET7 with chemical compounds


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