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Gene Review:

ANO7 - anoctamin 7

Homo sapiens

Synonyms: Anoctamin-7, D-TMPP, DTMPP, Dresden transmembrane protein of the prostate, IPCA-5, ...

Kiessling, A. et al., Katoh, M. et al., Das, S. et al.

Katoh, Katoh,

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Disease relevance of TMEM16G

TMEM16G mRNA was preferentially expressed in normal prostate and prostate cancer [1].
Our results suggest that NGEP-L has a role in promoting cell contact-dependent interactions of LNCaP prostate cancer cells and also that NGEP is a promising immunotherapy target for prostate cancer [2].

High impact information on TMEM16G

CONCLUSIONS: We describe the novel prostate-restricted molecule D-TMPP widely expressed in prostate cancer tissues [3].
In the androgen-dependent PCa cell line LNCaP, D-TMPP was upregulated by methyltrienolone [3].
The expression pattern of D-TMPP in malignant and nonmalignant tissues and tumor cell lines was analyzed by hybridization of a radioactively labeled cDNA probe with a multiple tissue expression array and by a quantitative real-time PCR assay [3].
Complete coding sequence of TMEM16G cDNA was determined by assembling 25 exons of TMEM16G gene [1].
Comparative proteomics revealed that T844N amino-acid substitution occurred in human TMEM16G during evolution [1].

Chemical compound and disease context of TMEM16G

D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family [3].

Biological context of TMEM16G

These facts indicate that amino-acid substitution at codon 844 of human TMEM16G resulted in the mis-folding of the eighth transmembrane helix [1].
Here, we characterized human TMEM16G gene by using bioinformatics [1].
TMEM16G gene, consisting of 25 exons, was located at human chromosome 2q37 [1].

References

Characterization of human TMEM16G gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2004) [Pubmed]
NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Das, S., Hahn, Y., Nagata, S., Willingham, M.C., Bera, T.K., Lee, B., Pastan, I. Cancer Res. (2007) [Pubmed]
D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family. Kiessling, A., Weigle, B., Fuessel, S., Ebner, R., Meye, A., Rieger, M.A., Schmitz, M., Temme, A., Bachmann, M., Wirth, M.P., Rieber, E.P. Prostate (2005) [Pubmed]

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ANO7	Canis lupus familiaris
si:dkey-83h2.5	Danio rerio
ANO7	Macaca mulatta
Ano7	Mus musculus
Ano7	Rattus norvegicus

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