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Gene Review

Fbxw7  -  F-box and WD-40 domain protein 7

Mus musculus

Synonyms: 1110001A17Rik, AGO, Cdc4, F-box and WD-40 domain-containing protein 7, F-box protein FBW7, ...
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Disease relevance of Fbxw7

  • Although p53-deficient mice primarily develop lymphomas and sarcomas, the additional loss of one copy of the Fbxw7 gene drives tumor development in a range of epithelial tissues [1].

High impact information on Fbxw7


Biological context of Fbxw7

  • Three isoforms (alpha, beta, and gamma) of Fbxw7 are produced from mRNAs with distinct 5' exons [4].

Regulatory relationships of Fbxw7

  • Our results thus indicate that expression of Fbxw7 isoforms is differentially regulated in a cell cycle- or p53-dependent manner [4].


  1. Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Perez-Losada, J., Mao, J.H., Balmain, A. Cancer Res. (2005) [Pubmed]
  2. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., Nakayama, K.I. EMBO J. (2004) [Pubmed]
  3. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T., Nakayama, K.I. J. Biol. Chem. (2004) [Pubmed]
  4. Expression of mouse Fbxw7 isoforms is regulated in a cell cycle- or p53-dependent manner. Matsumoto, A., Onoyama, I., Nakayama, K.I. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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