Gene Review:
Notch4 - notch 4
Mus musculus
Synonyms:
Int-3, Int3, N4, Neurogenic locus notch homolog protein 4, Notch 4
- Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Carlson, T.R., Yan, Y., Wu, X., Lam, M.T., Tang, G.L., Beverly, L.J., Messina, L.M., Capobianco, A.J., Werb, Z., Wang, R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Expression of an activated Notch4(int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cells in vitro. Soriano, J.V., Uyttendaele, H., Kitajewski, J., Montesano, R. Int. J. Cancer (2000)
- Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Takeshita, K., Satoh, M., Ii, M., Silver, M., Limbourg, F.P., Mukai, Y., Rikitake, Y., Radtke, F., Gridley, T., Losordo, D.W., Liao, J.K. Circ. Res. (2007)
- Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Gallahan, D., Jhappan, C., Robinson, G., Hennighausen, L., Sharp, R., Kordon, E., Callahan, R., Merlino, G., Smith, G.H. Cancer Res. (1996)
- A novel non-mouse mammary tumor virus activation of the Int-3 gene in a spontaneous mouse mammary tumor. Kordon, E.C., Smith, G.H., Callahan, R., Gallahan, D. J. Virol. (1995)
- Notch signaling is essential for vascular morphogenesis in mice. Krebs, L.T., Xue, Y., Norton, C.R., Shutter, J.R., Maguire, M., Sundberg, J.P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., Smith, G.H., Stark, K.L., Gridley, T. Genes Dev. (2000)
- Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Uyttendaele, H., Ho, J., Rossant, J., Kitajewski, J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- The Role of the Vascular Endothelial Growth Factor-Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions. Hainaud, P., Contrerès, J.O., Villemain, A., Liu, L.X., Plouët, J., Tobelem, G., Dupuy, E. Cancer Res. (2006)
- Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events. Lee, J.S., Haruna, T., Ishimoto, A., Honjo, T., Yanagawa, S. J. Virol. (1999)
- Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M.L., Weinmaster, G. Mech. Dev. (2001)
- Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis. Singh, N., Phillips, R.A., Iscove, N.N., Egan, S.E. Exp. Hematol. (2000)
- Developmental expression of the Notch signaling pathway genes during mouse preimplantation development. Cormier, S., Vandormael-Pournin, S., Babinet, C., Cohen-Tannoudji, M. Gene Expr. Patterns (2004)
- Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation. Vorontchikhina, M.A., Zimmermann, R.C., Shawber, C.J., Tang, H., Kitajewski, J. Gene Expr. Patterns (2005)
- Kit and PDGFR-alpha activities are necessary for Notch4/Int3-induced tumorigenesis. Raafat, A., Zoltan-Jones, A., Strizzi, L., Bargo, S., Kimura, K., Salomon, D., Callahan, R. Oncogene (2007)
- Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation. Wu, J., Bresnick, E.H. Mol. Cell. Biol. (2007)
- Notch gene expression during pancreatic organogenesis. Lammert, E., Brown, J., Melton, D.A. Mech. Dev. (2000)
- Understanding mammary gland development through the imbalanced expression of growth regulators. Robinson, G.W., Smith, G.H., Gallahan, D., Zimmer, A., Furth, P.A., Hennighausen, L. Dev. Dyn. (1996)
- Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis. Shirayoshi, Y., Yuasa, Y., Suzuki, T., Sugaya, K., Kawase, E., Ikemura, T., Nakatsuji, N. Genes Cells (1997)
- Molecular cloning of delta-4, a new mouse and human Notch ligand. Yoneya, T., Tahara, T., Nagao, K., Yamada, Y., Yamamoto, T., Osawa, M., Miyatani, S., Nishikawa, M. J. Biochem. (2001)