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Gene Review

Dkk3  -  dickkopf homolog 3 (Xenopus laevis)

Mus musculus

Synonyms: AW061014, C87148, Dickkopf-3, Dickkopf-related protein 3, Dkk-3, ...
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Disease relevance of Dkk3

  • REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer [1].
  • Expression of REIC/Dkk-3 was reduced in all of the human seminoma and non-seminomatous germ cell tumor tissues [1].

High impact information on Dkk3


Anatomical context of Dkk3

  • Postnatally, Dkk1 was prominently expressed in the preodonto- and odontoblasts, while Dkk3 mRNAs were transiently seen in the preameloblasts before the onset of enamel matrix secretion [4].


  1. REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer. Tanimoto, R., Abarzua, F., Sakaguchi, M., Takaishi, M., Nasu, Y., Kumon, H., Huh, N.H. Int. J. Mol. Med. (2007) [Pubmed]
  2. Generation and characterization of dickkopf3 mutant mice. Barrantes, I.d.e.l. .B., Montero-Pedrazuela, A., Guadaño-Ferraz, A., Obregon, M.J., Martinez de Mena, R., Gailus-Durner, V., Fuchs, H., Franz, T.J., Kalaydjiev, S., Klempt, M., Hölter, S., Rathkolb, B., Reinhard, C., Morreale de Escobar, G., Bernal, J., Busch, D.H., Wurst, W., Wolf, E., Schulz, H., Shtrom, S., Greiner, E., Hrabé de Angelis, M., Westphal, H., Niehrs, C. Mol. Cell. Biol. (2006) [Pubmed]
  3. Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. Caricasole, A., Ferraro, T., Iacovelli, L., Barletta, E., Caruso, A., Melchiorri, D., Terstappen, G.C., Nicoletti, F. J. Biol. Chem. (2003) [Pubmed]
  4. Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth. Fjeld, K., Kettunen, P., Furmanek, T., Kvinnsland, I.H., Luukko, K. Dev. Dyn. (2005) [Pubmed]
  5. Dkk1, -2, and -3 expression in mouse craniofacial development. Nie, X. Journal of molecular histology. (2005) [Pubmed]
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