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Gene Review:

Dkk3 - dickkopf homolog 3 (Xenopus laevis)

Mus musculus

Synonyms: AW061014, C87148, Dickkopf-3, Dickkopf-related protein 3, Dkk-3, ...

Fjeld, K. et al., Tanimoto, R. et al., Caricasole, A. et al., Barrantes, I.d.e.l. .B. et al., Nie, X.

Caricasole, Ferraro, Iacovelli, Barletta, Caruso, Melchiorri, Terstappen, Nicoletti, Nie,

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Disease relevance of Dkk3

REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer [1].
Expression of REIC/Dkk-3 was reduced in all of the human seminoma and non-seminomatous germ cell tumor tissues [1].

High impact information on Dkk3

Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels [2].
Our functional analysis indicates that WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by Dickkopf-1 and Dickkopf-3 [3].
Dkk2 was seen in the dental papilla, whereas Dkk3 was specifically expressed in the putative epithelial signaling centers, the primary and secondary enamel knots [4].
In the present study, we examined the potential utility of REIC/Dkk-3-based gene therapy against human testicular cancer [1].
During early craniofacial development, Dkk1 to Dkk3 show developmentally regulated expression in a number of elements [5].

Anatomical context of Dkk3

Postnatally, Dkk1 was prominently expressed in the preodonto- and odontoblasts, while Dkk3 mRNAs were transiently seen in the preameloblasts before the onset of enamel matrix secretion [4].

References

REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer. Tanimoto, R., Abarzua, F., Sakaguchi, M., Takaishi, M., Nasu, Y., Kumon, H., Huh, N.H. Int. J. Mol. Med. (2007) [Pubmed]
Generation and characterization of dickkopf3 mutant mice. Barrantes, I.d.e.l. .B., Montero-Pedrazuela, A., Guadaño-Ferraz, A., Obregon, M.J., Martinez de Mena, R., Gailus-Durner, V., Fuchs, H., Franz, T.J., Kalaydjiev, S., Klempt, M., Hölter, S., Rathkolb, B., Reinhard, C., Morreale de Escobar, G., Bernal, J., Busch, D.H., Wurst, W., Wolf, E., Schulz, H., Shtrom, S., Greiner, E., Hrabé de Angelis, M., Westphal, H., Niehrs, C. Mol. Cell. Biol. (2006) [Pubmed]
Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. Caricasole, A., Ferraro, T., Iacovelli, L., Barletta, E., Caruso, A., Melchiorri, D., Terstappen, G.C., Nicoletti, F. J. Biol. Chem. (2003) [Pubmed]
Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth. Fjeld, K., Kettunen, P., Furmanek, T., Kvinnsland, I.H., Luukko, K. Dev. Dyn. (2005) [Pubmed]
Dkk1, -2, and -3 expression in mouse craniofacial development. Nie, X. Journal of molecular histology. (2005) [Pubmed]

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DKK3	Bos taurus
DKK3	Canis lupus familiaris
dkk3b	Danio rerio
dkk3	Danio rerio
DKK3	Gallus gallus
DKK3	Homo sapiens
DKK3	Macaca mulatta
DKK3	Pan troglodytes
Dkk3	Rattus norvegicus

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