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Disease relevance of Odontoblasts


High impact information on Odontoblasts


Chemical compound and disease context of Odontoblasts


Biological context of Odontoblasts


Anatomical context of Odontoblasts


Associations of Odontoblasts with chemical compounds


Gene context of Odontoblasts

  • The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development [26].
  • Dentin sialophosphoprotein (Dspp) is mainly expressed in teeth by the odontoblasts and preameloblasts [27].
  • Osteocalcin (OC) is a matrix calcium-binding protein expressed in osteoblasts and odontoblasts undergoing mineralization [28].
  • In fully differentiated odontoblasts, the loss of interaction between Nrf1 and C/EBPbeta results in an increased DSPP transcription [29].
  • Moderate expression of Phex was seen in odontoblasts and slight immunoreactivity was observed in ameloblasts [30].

Analytical, diagnostic and therapeutic context of Odontoblasts


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  10. Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation. Chen, S., Rani, S., Wu, Y., Unterbrink, A., Gu, T.T., Gluhak-Heinrich, J., Chuang, H.H., Macdougall, M. J. Biol. Chem. (2005) [Pubmed]
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  16. Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide. Yoshiba, K., Yoshiba, N., Nakamura, H., Iwaku, M., Ozawa, H. J. Dent. Res. (1996) [Pubmed]
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  18. Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro. Tompkins, K., Alvares, K., George, A., Veis, A. J. Bone Miner. Res. (2005) [Pubmed]
  19. Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis. Bidder, M., Latifi, T., Towler, D.A. J. Bone Miner. Res. (1998) [Pubmed]
  20. Expression of rat bone sialoprotein promoter in transgenic mice. Chen, J., Thomas, H.F., Jin, H., Jiang, H., Sodek, J. J. Bone Miner. Res. (1996) [Pubmed]
  21. Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth. Kim, J.E., Nakashima, K., de Crombrugghe, B. Am. J. Pathol. (2004) [Pubmed]
  22. Extracellular Ca2+ increases cytosolic free Ca2+ in freshly isolated rat odontoblasts. Guo, L., Davidson, R.M. J. Bone Miner. Res. (1999) [Pubmed]
  23. Tunicamycin-induced alterations in basement membrane formation during odontoblast differentiation. Thesleff, I., Pratt, R.M. Dev. Biol. (1980) [Pubmed]
  24. The biosynthesis of dentine gamma-carboxyglutamic acid-containing proteins by rat incisor odontoblasts in organ culture. DiMuzio, M.T., Bhown, M., Butler, W.T. Biochem. J. (1983) [Pubmed]
  25. The extent of the odontoblast process in human dentin. Thomas, H.F. J. Dent. Res. (1979) [Pubmed]
  26. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., Lu, Y., Mishina, Y., Feng, J.Q. J. Biol. Chem. (2004) [Pubmed]
  27. Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. Sreenath, T., Thyagarajan, T., Hall, B., Longenecker, G., D'Souza, R., Hong, S., Wright, J.T., MacDougall, M., Sauk, J., Kulkarni, A.B. J. Biol. Chem. (2003) [Pubmed]
  28. Stimulus-selective inhibition of rat osteocalcin promoter induction and protein-DNA interactions by the homeodomain repressor Msx2. Newberry, E.P., Boudreaux, J.M., Towler, D.A. J. Biol. Chem. (1997) [Pubmed]
  29. The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. Narayanan, K., Ramachandran, A., Peterson, M.C., Hao, J., Kolstø, A.B., Friedman, A.D., George, A. J. Biol. Chem. (2004) [Pubmed]
  30. Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts. Thompson, D.L., Sabbagh, Y., Tenenhouse, H.S., Roche, P.C., Drezner, M.K., Salisbury, J.L., Grande, J.P., Poeschla, E.M., Kumar, R. J. Bone Miner. Res. (2002) [Pubmed]
  31. Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. MacDougall, M., Gu, T.T., Luan, X., Simmons, D., Chen, J. J. Bone Miner. Res. (1998) [Pubmed]
  32. The activin-binding protein follistatin is expressed in developing murine molar and induces odontoblast-like cell differentiation in vitro. Heikinheimo, K., Bègue-Kirn, C., Ritvos, O., Tuuri, T., Ruch, J.V. J. Dent. Res. (1997) [Pubmed]
  33. Localization of estrogen-receptor-related antigen in human odontoblasts. Hietala, E.L., Larmas, M., Salo, T. J. Dent. Res. (1998) [Pubmed]
  34. The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1. Palosaari, H., Wahlgren, J., Larmas, M., Rönkä, H., Sorsa, T., Salo, T., Tjäderhane, L. J. Dent. Res. (2000) [Pubmed]
  35. Expression of amelogenin in odontoblasts. Papagerakis, P., MacDougall, M., Hotton, D., Bailleul-Forestier, I., Oboeuf, M., Berdal, A. Bone (2003) [Pubmed]
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