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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Seminoma


High impact information on Seminoma


Chemical compound and disease context of Seminoma

  • Simple nontoxic treatment of advanced metastatic seminoma with carboplatin [4].
  • CONCLUSION: Most patients with advanced seminoma are cured with standard first-line programs of cisplatin and etoposide with or without bleomycin [11].
  • We therefore feel that gallium scans have minimal value in the prechemotherapy or postchemotherapy evaluation of metastatic seminoma [12].
  • Two patients had concomitant malignancy (chronic monomyelogenous leukemia and retroperitoneal seminoma respectively) and 1 patient developed immunoblastic sarcoma in the opposite hemisphere after biopsy diagnosis and steroid treatment of her demyelinating lesion [13].
  • The alpha 5 integrin subunit was weakly expressed in primary seminomas in all stages [14].

Biological context of Seminoma

  • In contrast, seminomas lacking a restricted 12p amplification, showing significantly lower levels of DAD-R with pronounced apoptosis, manifest clinically in the fourth decade of life [15].
  • This is the first description of an activating c-kit mutation in GCTs and is evidence that the KIT signal transduction pathway is important in the pathogenesis of neoplasms with seminoma differentiation [16].
  • RASSF1A methylation was detected in four of 10 (40%) seminomas and 15 of 18 (83%) nonseminoma TGCT (NSTGCT) components (P=0.0346) [17].
  • These results indicate to a major difference in telomeric length between seminomas and nonseminomas, which is apparently unrelated to the presence of telomerase activity, and suggest a germline-like homeostasis of telomeric length is preserved in human nonseminomas [18].
  • Storage of Cx43 in the Golgi apparatus may correspond during spermatogenesis to an intermittent physiological process that becomes permanent in malignant seminoma cells as a result of the tumourigenic process [19].

Anatomical context of Seminoma

  • Increases were noted in the frequencies of Aw33, B5, DR5, and DRw6 among the patients with pure seminoma, A3 and B7 among the patients with embryonal carcinoma with or without seminoma, and Aw32 among the patients with yolk sac tumor components [20].
  • The number of CD3(+), CD8(+), TIA-1(+), and granzyme B(+) cells in tumour cell nests was markedly increased in testicular seminomas, compared with NSTGCTs (p<0.01) [21].
  • These similarities suggest that the increased expression of PLAP-like enzymes in seminomas results from enhanced eutopic expression of enzymes found in normal testis [22].
  • The ETV4 protein was localised to nuclei of spermatogonia and revealed an intense staining in seminoma cells [23].
  • METHODS AND MATERIALS: The study was carried out in 25 centers in Germany. Patients with pure seminoma, negative AFP-values, and retroperitoneal lymph node metastases of less than 5 cm in diameter were entered into the study [24].

Gene context of Seminoma

  • In addition, our results also imply differences in expression regulation of DAD-R between seminomas and nonseminomas [15].
  • Immunohistological analysis confirmed the loss of expression of SMAD4 protein in the seminoma tissues with the insertional mutation [25].
  • Sixty-four percent of the seminomas and 23% of the non-seminomas had decreased expression of CDK6 by a mean factor of 5 (P = 0.009) [26].
  • The classical seminomas showed vimentin positivity, but this was usually observed in a small number of tumor cells [27].
  • In the second mixed germ cell tumour, the NSTGCT component was methylated for RASSF1A and MGMT, while the seminoma component was methylated only for RASSF1A [17].

Analytical, diagnostic and therapeutic context of Seminoma


  1. Inhibition by alkyl-lysophospholipids of tritiated thymidine uptake in cells of human malignant urologic tumors. Berdel, W.E., Fink, U., Egger, B., Reichert, A., Munder, P.G., Rastetter, J. J. Natl. Cancer Inst. (1981) [Pubmed]
  2. Blood group-related antigens in human germ cell tumors. Motzer, R.J., Reuter, V.E., Cordon-Cardo, C., Bosl, G.J. Cancer Res. (1988) [Pubmed]
  3. Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Robertson, K.A., Bullock, H.A., Xu, Y., Tritt, R., Zimmerman, E., Ulbright, T.M., Foster, R.S., Einhorn, L.H., Kelley, M.R. Cancer Res. (2001) [Pubmed]
  4. Simple nontoxic treatment of advanced metastatic seminoma with carboplatin. Horwich, A., Dearnaley, D.P., Duchesne, G.M., Williams, M., Brada, M., Peckham, M.J. J. Clin. Oncol. (1989) [Pubmed]
  5. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. Heinrich, M.C., Blanke, C.D., Druker, B.J., Corless, C.L. J. Clin. Oncol. (2002) [Pubmed]
  6. Seminoma and epididymal cysts in a young man with known diethylstilbestrol exposure in utero. Conley, G.R., Sant, G.R., Ucci, A.A., Mitcheson, H.D. JAMA (1983) [Pubmed]
  7. Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. Motzer, R.J., Rodriguez, E., Reuter, V.E., Samaniego, F., Dmitrovsky, E., Bajorin, D.F., Pfister, D.G., Parsa, N.Z., Chaganti, R.S., Bosl, G.J. J. Natl. Cancer Inst. (1991) [Pubmed]
  8. False positivity with one-step and conventional ELISA for alpha-fetoprotein in seminoma. Veress, L., Szabio, n.u.l.l., Papp, Z. Lancet (1989) [Pubmed]
  9. The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Nathanson, K.L., Kanetsky, P.A., Hawes, R., Vaughn, D.J., Letrero, R., Tucker, K., Friedlander, M., Phillips, K.A., Hogg, D., Jewett, M.A., Lohynska, R., Daugaard, G., Richard, S., Chompret, A., Bonaïti-Pellié, C., Heidenreich, A., Olah, E., Geczi, L., Bodrogi, I., Ormiston, W.J., Daly, P.A., Oosterhuis, J.W., Gillis, A.J., Looijenga, L.H., Guilford, P., Fosså, S.D., Heimdal, K., Tjulandin, S.A., Liubchenko, L., Stoll, H., Weber, W., Rudd, M., Huddart, R., Crockford, G.P., Forman, D., Oliver, D.T., Einhorn, L., Weber, B.L., Kramer, J., McMaster, M., Greene, M.H., Pike, M., Cortessis, V., Chen, C., Schwartz, S.M., Bishop, D.T., Easton, D.F., Stratton, M.R., Rapley, E.A. Am. J. Hum. Genet. (2005) [Pubmed]
  10. TCL1 participates in early embryonic development and is overexpressed in human seminomas. Narducci, M.G., Fiorenza, M.T., Kang, S.M., Bevilacqua, A., Di Giacomo, M., Remotti, D., Picchio, M.C., Fidanza, V., Cooper, M.D., Croce, C.M., Mangia, F., Russo, G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. Salvage chemotherapy for patients with advanced pure seminoma. Vuky, J., Tickoo, S.K., Sheinfeld, J., Bacik, J., Amsterdam, A., Mazumdar, M., Reuter, V., Bajorin, D.F., Bosl, G.J., Motzer, R.J. J. Clin. Oncol. (2002) [Pubmed]
  12. Gallium scans in the evaluation of residual masses after chemotherapy for seminoma. Warren, G.P., Einhorn, L.H. J. Clin. Oncol. (1995) [Pubmed]
  13. Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients. Kepes, J.J. Ann. Neurol. (1993) [Pubmed]
  14. The tumor microenvironment: possible role of integrins and the extracellular matrix in tumor biological behavior of intratubular germ cell neoplasia and testicular seminomas. Timmer, A., Oosterhuis, J.W., Schraffordt Koops, H., Sleijfer, D.T., Szabo, B.G., Timens, W. Am. J. Pathol. (1994) [Pubmed]
  15. Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. Zafarana, G., Gillis, A.J., van Gurp, R.J., Olsson, P.G., Elstrodt, F., Stoop, H., Millán, J.L., Oosterhuis, J.W., Looijenga, L.H. Cancer Res. (2002) [Pubmed]
  16. Activating c-kit gene mutations in human germ cell tumors. Tian, Q., Frierson, H.F., Krystal, G.W., Moskaluk, C.A. Am. J. Pathol. (1999) [Pubmed]
  17. Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours. Honorio, S., Agathanggelou, A., Wernert, N., Rothe, M., Maher, E.R., Latif, F. Oncogene (2003) [Pubmed]
  18. Germ cell-like telomeric length homeostasis in nonseminomatous testicular germ cell tumors. Nowak, R., Sikora, K., Pietas, A., Skoneczna, I., Chrapusta, S.J. Oncogene (2000) [Pubmed]
  19. Disrupted traffic of connexin 43 in human testicular seminoma cells: overexpression of Cx43 induces membrane location and cell proliferation decrease. Roger, C., Mograbi, B., Chevallier, D., Michiels, J.F., Tanaka, H., Segretain, D., Pointis, G., Fenichel, P. J. Pathol. (2004) [Pubmed]
  20. HLA antigens in patients with germ cell cancers of the testis. Pollack, M.S., Vugrin, D., Hennessy, W., Herr, H.W., Dupont, B., Whitmore, W.F. Cancer Res. (1982) [Pubmed]
  21. Activated status of tumour-infiltrating lymphocytes and apoptosis in testicular seminoma. Yakirevich, E., Lefel, O., Sova, Y., Stein, A., Cohen, O., Izhak, O.B., Resnick, M.B. J. Pathol. (2002) [Pubmed]
  22. Eutopic expression of placental-like alkaline phosphatase in testicular tumors. Jeppsson, A., Wahren, B., Brehmer-Andersson, E., Silfverswärd, C., Stigbrand, T., Millán, J.L. Int. J. Cancer (1984) [Pubmed]
  23. Gene signatures of testicular seminoma with emphasis on expression of ets variant gene 4. Gashaw, I., Grümmer, R., Klein-Hitpass, L., Dushaj, O., Bergmann, M., Brehm, R., Grobholz, R., Kliesch, S., Neuvians, T.P., Schmid, K.W., von Ostau, C., Winterhager, E. Cell. Mol. Life Sci. (2005) [Pubmed]
  24. Radiotherapy in stage IIA and IIB testicular seminoma with reduced portals: a prospective multicenter study. Schmidberger, H., Bamberg, M., Meisner, C., Classen, J., Winkler, C., Hartmann, M., Templin, R., Wiegel, T., Dornoff, W., Ross, D., Thiel, H.J., Martini, C., Haase, W. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
  25. A novel SMAD4 gene mutation in seminoma germ cell tumors. Bouras, M., Tabone, E., Bertholon, J., Sommer, P., Bouvier, R., Droz, J.P., Benahmed, M. Cancer Res. (2000) [Pubmed]
  26. Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Schmidt, B.A., Rose, A., Steinhoff, C., Strohmeyer, T., Hartmann, M., Ackermann, R. Cancer Res. (2001) [Pubmed]
  27. Intermediate filament proteins in human testis and testicular germ-cell tumors. Miettinen, M., Virtanen, I., Talerman, A. Am. J. Pathol. (1985) [Pubmed]
  28. The treatment of advanced metastatic seminoma: experience in 55 cases. Fosså, S.D., Borge, L., Aass, N., Johannessen, N.B., Stenwig, A.E., Kaalhus, O. J. Clin. Oncol. (1987) [Pubmed]
  29. Optimal planning target volume for stage I testicular seminoma: A Medical Research Council randomized trial. Medical Research Council Testicular Tumor Working Group. Fosså, S.D., Horwich, A., Russell, J.M., Roberts, J.T., Cullen, M.H., Hodson, N.J., Jones, W.G., Yosef, H., Duchesne, G.M., Owen, J.R., Grosch, E.J., Chetiyawardana, A.D., Reed, N.S., Widmer, B., Stenning, S.P. J. Clin. Oncol. (1999) [Pubmed]
  30. Human chorionic gonadotropin (hCG) and its free subunits in hydrocele fluids and neoplastic tissue of testicular cancer patients: insights into the in vivo hCG-secretion pattern. Madersbacher, S., Kratzik, C., Gerth, R., Dirnhofer, S., Berger, P. Cancer Res. (1994) [Pubmed]
  31. Alkaline phosphatase isozymes in human testicular germ cell tumors, their precancerous stage, and three related cell lines. Hofmann, M.C., Jeltsch, W., Brecher, J., Walt, H. Cancer Res. (1989) [Pubmed]
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