The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TAS2R16  -  taste receptor, type 2, member 16

Homo sapiens

Synonyms: T2R16, Taste receptor type 2 member 16
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on TAS2R16


High impact information on TAS2R16

  • Bitter compounds consisting of a hydrophobic residue attached to glucose by a beta-glycosidic bond activate TAS2R16 [2].
  • A coding single-nucleotide polymorphism (cSNP), K172N, in hTAS2R16, a gene encoding a taste receptor for bitter beta -glucopyranosides, shows significant association with alcohol dependence (P = .00018) [3].
  • The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity [4].
  • RESULTS: We examined evidence for natural selection on the human receptor TAS2R16 by sequencing the entire coding region, as well as part of the 5' and 3' UTRs, in 997 individuals from 60 human populations [4].
  • In contrast to the previously reported significant association between TAS2R16 and alcohol dependence, we found no evidence that TAS2R38 haplotypes influence alcohol dependence in the COGA dataset [1].

Biological context of TAS2R16

  • We have previously reported that a missense mutation in the TAS2R16 gene reduces the sensitivity of the receptor to bitter-taste stimuli and that it is associated with risk for alcohol dependence [1].
  • We have also extended our analysis of TAS2R16 to include the Maxdrinks phenotype [1].

Associations of TAS2R16 with chemical compounds

  • The expression in ASI neurons of human T2R16, the ligand of which, phenyl-beta-d-glucopyranoside, belong to a chemically different group of bitter tastants, also counteracted the water-soluble avoidance to this compound observed in wild-type worms [5].
  • Functional Variants in TAS2R38 and TAS2R16 Influence Alcohol Consumption in High-Risk Families of African-American Origin [1].

Analytical, diagnostic and therapeutic context of TAS2R16


  1. Functional Variants in TAS2R38 and TAS2R16 Influence Alcohol Consumption in High-Risk Families of African-American Origin. Wang, J.C., Hinrichs, A.L., Bertelsen, S., Stock, H., Budde, J.P., Dick, D.M., Bucholz, K.K., Rice, J., Saccone, N., Edenberg, H.J., Hesselbrock, V., Kuperman, S., Schuckit, M.A., Bierut, L.J., Goate, A.M. Alcohol. Clin. Exp. Res. (2007) [Pubmed]
  2. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe, B., Hofmann, T., Krautwurst, D., Raguse, J.D., Meyerhof, W. Nat. Genet. (2002) [Pubmed]
  3. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Hinrichs, A.L., Wang, J.C., Bufe, B., Kwon, J.M., Budde, J., Allen, R., Bertelsen, S., Evans, W., Dick, D., Rice, J., Foroud, T., Nurnberger, J., Tischfield, J.A., Kuperman, S., Crowe, R., Hesselbrock, V., Schuckit, M., Almasy, L., Porjesz, B., Edenberg, H.J., Begleiter, H., Meyerhof, W., Bierut, L.J., Goate, A.M. Am. J. Hum. Genet. (2006) [Pubmed]
  4. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Soranzo, N., Bufe, B., Sabeti, P.C., Wilson, J.F., Weale, M.E., Marguerie, R., Meyerhof, W., Goldstein, D.B. Curr. Biol. (2005) [Pubmed]
  5. Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans. Conte, C., Guarin, E., Marcuz, A., Andres-Barquin, P.J. Biochimie (2006) [Pubmed]
  6. Members of RTP and REEP gene families influence functional bitter taste receptor expression. Behrens, M., Bartelt, J., Reichling, C., Winnig, M., Kuhn, C., Meyerhof, W. J. Biol. Chem. (2006) [Pubmed]
WikiGenes - Universities