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Gene Review

TAS2R38  -  taste receptor, type 2, member 38

Homo sapiens

Synonyms: PTC, PTC bitter taste receptor, T2R38, T2R61, Taste receptor type 2 member 38, ...
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Disease relevance of TAS2R38


Psychiatry related information on TAS2R38


High impact information on TAS2R38


Biological context of TAS2R38


Associations of TAS2R38 with chemical compounds


Other interactions of TAS2R38

  • In contrast to the previously reported significant association between TAS2R16 and alcohol dependence, we found no evidence that TAS2R38 haplotypes influence alcohol dependence in the COGA dataset [2].


  1. TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. Timpson, N.J., Christensen, M., Lawlor, D.A., Gaunt, T.R., Day, I.N., Ebrahim, S., Davey Smith, G. Am. J. Clin. Nutr. (2005) [Pubmed]
  2. Functional Variants in TAS2R38 and TAS2R16 Influence Alcohol Consumption in High-Risk Families of African-American Origin. Wang, J.C., Hinrichs, A.L., Bertelsen, S., Stock, H., Budde, J.P., Dick, D.M., Bucholz, K.K., Rice, J., Saccone, N., Edenberg, H.J., Hesselbrock, V., Kuperman, S., Schuckit, M.A., Bierut, L.J., Goate, A.M. Alcohol. Clin. Exp. Res. (2007) [Pubmed]
  3. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Bufe, B., Breslin, P.A., Kuhn, C., Reed, D.R., Tharp, C.D., Slack, J.P., Kim, U.K., Drayna, D., Meyerhof, W. Curr. Biol. (2005) [Pubmed]
  4. Inhibition of erythroid progenitor growth is mediated by cytotoxic lymphocytes and not by natural killer cells or IFN-gamma. Torok-Storb, B., Graf, L., Shankar, P. J. Immunol. (1989) [Pubmed]
  5. Colocalization of the {alpha}-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Rozengurt, N., Wu, S.V., Chen, M.C., Huang, C., Sternini, C., Rozengurt, E. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  6. Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Duffy, V.B., Davidson, A.C., Kidd, J.R., Kidd, K.K., Speed, W.C., Pakstis, A.J., Reed, D.R., Snyder, D.J., Bartoshuk, L.M. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
  7. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Prodi, D.A., Drayna, D., Forabosco, P., Palmas, M.A., Maestrale, G.B., Piras, D., Pirastu, M., Angius, A. Chem. Senses (2004) [Pubmed]
  8. Identification of ligands for two human bitter T2R receptors. Pronin, A.N., Tang, H., Connor, J., Keung, W. Chem. Senses (2004) [Pubmed]
  9. Computational studies of ligand-receptor interactions in bitter taste receptors. Miguet, L., Zhang, Z., Grigorov, M.G. J. Recept. Signal Transduct. Res. (2006) [Pubmed]
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