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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Exosc9  -  exosome component 9

Mus musculus

Synonyms: Autoantigen PM/Scl 1, Exosome complex component RRP45, Exosome component 9, P75 polymyositis-scleroderma overlap syndrome-associated autoantigen, PM/Scl-75, ...
 
 
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High impact information on Exosc9

  • In both cases, the inhibitory effect was independent of AAV DNA replication but required the AAV p5 and p19 genes, which encode proteins required for AAV DNA replication and regulation of AAV gene expression [1].
  • Complete mouse Pmscl1 and Pmscl2 cDNA sequences, chromosomal localizations, exon/intron structure, and promoter region sequences of the mouse Pmscl2 gene are presented [2].
  • Animals were intraperitoneally sensitized with Dermatophagoides pteronyssinus group-5 allergen (Der p 5) and orally treated with recombinant LAB containing a plasmid-encoded Der p 5 gene or placebo on day 7 and day 14 for three days consecutively [3].
 

Analytical, diagnostic and therapeutic context of Exosc9

  • Der p 5-specific immunological responses including changes to specific immunoglobulin G and E (IgE) levels, the presence of cells in the bronchoalveolar lavage fluid (BALF), and AHR were assessed following this inhalational challenge [3].

References

  1. Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes. Labow, M.A., Graf, L.H., Berns, K.I. Mol. Cell. Biol. (1987) [Pubmed]
  2. Structure and localization of mouse Pmscl1 and Pmscl2 genes. Bliskovski, V., Liddell, R., Ramsay, E.S., Miller, M.J., Mock, B.A. Genomics (2000) [Pubmed]
  3. Inhibition of allergen-induced airway inflammation and hyperreactivity by recombinant lactic-acid bacteria. Charng, Y.C., Lin, C.C., Hsu, C.H. Vaccine (2006) [Pubmed]
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