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Disease relevance of Pyroglyphidae


High impact information on Pyroglyphidae

  • We have characterized the protease activity of Der p I, the group I protease allergen of the house dust mite Dermatophagoides pteronyssinus, and here report that it cleaves the low-affinity immunoglobulin (Ig) E Fc receptor (CD23) from the surface of human B lymphocytes [6].
  • A group of patients with allergic rhinitis had a clinical history strongly suggestive of house-dust-mite (Dermatophagoides pteronyssinus) allergy but negative skin reactions when prick tested with D. pteronyssinus extracts [7].
  • In vitro pulmonary gamma delta T-cell proliferation in response to a specific allergen, the apoptotic death of these cells after incubation with 10(-7) M dexamethasone, and bronchoalveolar lavage fluid T-lymphocyte composition before and after 1 week of deflazacort therapy were evaluated in 3 Dermatophagoides pteronyssinus-sensitive patients [8].
  • PBMC from asthmatics allergic to house dust mite cultured in the presence of Dermatophagoides pteronyssinus 1 (Der p 1) allergen secreted CCL18, 48 and 72 h after stimulation, whereas those from healthy donors did not [9].
  • Most house dust mite allergic patients react to Der p 1 from Dermatophagoides pteronyssinus, which is a cysteine protease [10].

Chemical compound and disease context of Pyroglyphidae


Biological context of Pyroglyphidae


Anatomical context of Pyroglyphidae

  • The group 1 allergen of Dermatophagoides spp. is a major target antigen in both B and T cell recognition of HDM [19].
  • Both mild and moderate asthmatic explants showed significantly elevated Dermatophagoides pteronyssinus -induced release of TLCA, but only in mild asthma could sputum and allergen-stimulated explant TLCA be inhibited by anti-IL-16 (median inhibition, 39% and 59%; P <.05) [20].
  • OBJECTIVE: Because Der p 1, a cysteine protease allergen from Dermatophagoides pteronyssinus , induces chemokine production by bronchial epithelial cells (BECs), the purpose of this investigation was to evaluate the capacity of BEC exposed to Der p 1 to recruit DCs [21].
  • The effect of blocking nitrocellulose membranes with the nonionic detergent Tween 20 on the detection, by protein blotting, of IgE-binding to house dust mite Dermatophagoides pteronyssinus allergens has been investigated [22].
  • In the present study, we examined the effect of curcumin on the production of interleukin (IL)-2, IL-5, granulocyte macrophage-colony stimulating factor (GM-CSF), and IL-4 by lymphocytes from atopic asthmatics in response to house dust mites (Dermatophagoides farinea: Df) in order to clarify a potential application for allergic diseases [23].

Associations of Pyroglyphidae with chemical compounds


Gene context of Pyroglyphidae


Analytical, diagnostic and therapeutic context of Pyroglyphidae


  1. T cell responses to the major allergen from the house dust mite Dermatophagoides pteronyssinus, Antigen P1: comparison of patients with asthma, atopic dermatitis, and perennial rhinitis. Rawle, F.C., Mitchell, E.B., Platts-Mills, T.A. J. Immunol. (1984) [Pubmed]
  2. The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent. Tournoy, K.G., Kips, J.C., Pauwels, R.A. J. Immunol. (2001) [Pubmed]
  3. Benzyl benzoate moist powder: investigation of acaricidal [correction of acarical] activity in cultures and reduction of dust mite allergens in carpets. Hayden, M.L., Rose, G., Diduch, K.B., Domson, P., Chapman, M.D., Heymann, P.W., Platts-Mills, T.A. J. Allergy Clin. Immunol. (1992) [Pubmed]
  4. Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis. Kanda, N., Watanabe, S. J. Invest. Dermatol. (2001) [Pubmed]
  5. An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro. Kamal, A.M., Smith, S.F., De Silva Wijayasinghe, M., Solito, E., Corrigan, C.J. Clin. Exp. Allergy (2001) [Pubmed]
  6. A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases. Hewitt, C.R., Brown, A.P., Hart, B.J., Pritchard, D.I. J. Exp. Med. (1995) [Pubmed]
  7. Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests. Huggins, K.G., Brostoff, J. Lancet (1975) [Pubmed]
  8. Increased allergen-specific, steroid-sensitive gamma delta T cells in bronchoalveolar lavage fluid from patients with asthma. Spinozzi, F., Agea, E., Bistoni, O., Forenza, N., Monaco, A., Bassotti, G., Nicoletti, I., Riccardi, C., Grignani, F., Bertotto, A. Ann. Intern. Med. (1996) [Pubmed]
  9. Involvement of CCL18 in Allergic Asthma. Nadaï, P., Charbonnier, A.S., Chenivesse, C., Sénéchal, S., Fournier, C., Gilet, J., Vorng, H., Chang, Y., Gosset, P., Wallaert, B., Tonnel, A.B., Lassalle, P., Tsicopoulos, A. J. Immunol. (2006) [Pubmed]
  10. The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen. Meno, K., Thorsted, P.B., Ipsen, H., Kristensen, O., Larsen, J.N., Spangfort, M.D., Gajhede, M., Lund, K. J. Immunol. (2005) [Pubmed]
  11. Rapid expression of the CD69 antigen on T cells and natural killer cells upon antigenic stimulation of peripheral blood mononuclear cell suspensions. Werfel, T., Boeker, M., Kapp, A. Allergy (1997) [Pubmed]
  12. Regulation of peripheral blood mononuclear cell responses to Dermatophagoides farinae by substance P in patients with atopic dermatitis. Yokote, R., Yagi, H., Furukawa, F., Takigawa, M. Arch. Dermatol. Res. (1998) [Pubmed]
  13. Potentiation of histamine release against inhalant allergens (Dermatophagoides pteronyssinus) with bacterial antigens in bronchial asthma. Oehling, A., Aguila de la Coba, R., Fernández, M., Leyva, J., Sanz, M.L., Resano, A. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. (1997) [Pubmed]
  14. The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen. Lind, P., Hansen, O.C., Horn, N. J. Immunol. (1988) [Pubmed]
  15. Bronchial allergen challenge with isolated major allergens of Dermatophagoides pteronyssinus: the role of patient characteristics in the early asthmatic response. van der Veen, M.J., Lopuhaä, C.E., Aalberse, R.C., Jansen, H.M., van der Zee, J.S. J. Allergy Clin. Immunol. (1998) [Pubmed]
  16. Kinetics of allergen release from house dust mite Dermatophagoides pteronyssinus. Geissler, W., Maasch, H.J., Winter, G., Wahl, R. J. Allergy Clin. Immunol. (1986) [Pubmed]
  17. Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 conditions T cells to produce more IL-4 and less IFN-gamma. Ghaemmaghami, A.M., Robins, A., Gough, L., Sewell, H.F., Shakib, F. Eur. J. Immunol. (2001) [Pubmed]
  18. The human immune response against major allergens from house dust mite, Dermatophagoides pteronyssinus. II. Idiotypic cross-reactions of allergen-specific antibodies. Saint-Remy, J.M., Lebrun, P.M., Lebecque, S.J., Masson, P.L. Eur. J. Immunol. (1986) [Pubmed]
  19. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. Hoyne, G.F., O'Hehir, R.E., Wraith, D.C., Thomas, W.R., Lamb, J.R. J. Exp. Med. (1993) [Pubmed]
  20. Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals. Dent, G., Hosking, L.A., Lordan, J.L., Steel, M.D., Cruikshank, W.W., Center, D.M., Ellis, J.H., Holgate, S.T., Davies, D.E., Djukanović, R. J. Allergy Clin. Immunol. (2002) [Pubmed]
  21. Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. Pichavant, M., Charbonnier, A.S., Taront, S., Brichet, A., Wallaert, B., Pestel, J., Tonnel, A.B., Gosset, P. J. Allergy Clin. Immunol. (2005) [Pubmed]
  22. Enhanced immunodetection of blotted house dust mite protein allergens on nitrocellulose following blocking with Tween 20. Tovey, E.R., Ford, S.A., Baldo, B.A. Electrophoresis (1989) [Pubmed]
  23. Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Kobayashi, T., Hashimoto, S., Horie, T. Biochem. Pharmacol. (1997) [Pubmed]
  24. Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases. Chua, K.Y., Stewart, G.A., Thomas, W.R., Simpson, R.J., Dilworth, R.J., Plozza, T.M., Turner, K.J. J. Exp. Med. (1988) [Pubmed]
  25. The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma. Comoy, E.E., Pestel, J., Duez, C., Stewart, G.A., Vendeville, C., Fournier, C., Finkelman, F., Capron, A., Thyphronitis, G. J. Immunol. (1998) [Pubmed]
  26. Skin tests and histamine release with P1-depleted Dermatophagoides pteronyssinus body extracts and purified P1. van der Zee, J.S., van Swieten, P., Jansen, H.M., Aalberse, R.C. J. Allergy Clin. Immunol. (1988) [Pubmed]
  27. The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite Dermatophagoides pteronyssinus. King, C., Simpson, R.J., Moritz, R.L., Reed, G.E., Thompson, P.J., Stewart, G.A. J. Allergy Clin. Immunol. (1996) [Pubmed]
  28. The effectiveness of benzyl benzoate and some essential plant oils as laundry additives for killing house dust mites. McDonald, L.G., Tovey, E. J. Allergy Clin. Immunol. (1993) [Pubmed]
  29. Mite-specific induction of interleukin-2 receptor on T lymphocytes from children with mite-sensitive asthma: modified immune response with immunotherapy. Bonno, M., Fujisawa, T., Iguchi, K., Uchida, Y., Kamiya, H., Komada, Y., Sakurai, M. J. Allergy Clin. Immunol. (1996) [Pubmed]
  30. Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production. Cosmi, L., Santarlasci, V., Angeli, R., Liotta, F., Maggi, L., Frosali, F., Rossi, O., Falagiani, P., Riva, G., Romagnani, S., Annunziato, F., Maggi, E. Clin. Exp. Allergy (2006) [Pubmed]
  31. Effect of cytokines on spontaneous and allergen-induced CD23 expression, sCD23 release and Ig(E,G) synthesis from peripheral blood lymphocytes. Pfeil, T., Fischer, A., Bujanowski-Weber, J., Luther, H., Altmeyer, P., König, W. Immunology (1989) [Pubmed]
  32. Functional CD86 (B7-2/B70) is predominantly expressed on Langerhans cells in atopic dermatitis. Ohki, O., Yokozeki, H., Katayama, I., Umeda, T., Azuma, M., Okumura, K., Nishioka, K. Br. J. Dermatol. (1997) [Pubmed]
  33. Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression. Schaub, B., Campo, M., He, H., Perkins, D., Gillman, M.W., Gold, D.R., Weiss, S., Lieberman, E., Finn, P.W. Respir. Res. (2006) [Pubmed]
  34. Stimulation of alveolar macrophages in asthmatic patients after local provocation test. Tonnel, A.B., Joseph, M., Gosset, P., Fournier, E., Capron, A. Lancet (1983) [Pubmed]
  35. The kinetics of change in cytokine production by CD4 T cells during conventional allergen immunotherapy. Benjaponpitak, S., Oro, A., Maguire, P., Marinkovich, V., DeKruyff, R.H., Umetsu, D.T. J. Allergy Clin. Immunol. (1999) [Pubmed]
  36. Monoclonal immunoassays for major dust mite (Dermatophagoides) allergens, Der p I and Der f I, and quantitative analysis of the allergen content of mite and house dust extracts. Chapman, M.D., Heymann, P.W., Wilkins, S.R., Brown, M.J., Platts-Mills, T.A. J. Allergy Clin. Immunol. (1987) [Pubmed]
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