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Gene Review:

PSME2 - proteasome (prosome, macropain) activator...

Bos taurus

Liu, G. et al., Wilk, S. et al.

Wilk, Chen, Magnusson,

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Disease relevance of PSME2

PA28beta produced in an Escherichia coli expression system migrates on a calibrated gel filtration column as an apparent heptamer (Mr = 250,000) [1].

High impact information on PSME2

At concentrations which favor oligomerization (> 2 microM), PA28beta is a strong proteasome activator although its affinity for the proteasome is about 10-fold less than recombinant PA28alpha [1].
Molecular cloning of proteasome activator PA28-beta subunit of large yellow croaker (Pseudosciana crocea) and its coordinated up-regulation with MHC class I alpha-chain and beta(2)-microglobulin in poly I:C-treated fish [2].

References

Properties of the beta subunit of the proteasome activator PA28 (11S REG). Wilk, S., Chen, W.E., Magnusson, R.P. Arch. Biochem. Biophys. (2000) [Pubmed]
Molecular cloning of proteasome activator PA28-beta subunit of large yellow croaker (Pseudosciana crocea) and its coordinated up-regulation with MHC class I alpha-chain and beta(2)-microglobulin in poly I:C-treated fish. Liu, G., Zheng, W., Chen, X. Mol. Immunol. (2007) [Pubmed]

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PSME2	Canis lupus familiaris
psme2	Danio rerio
PSME2	Homo sapiens
PSME2	Macaca mulatta
Psme2	Mus musculus
PSME2	Pan troglodytes
Psme2	Rattus norvegicus
LOC100362709	Rattus norvegicus
psme2	Xenopus (Silurana) tropicalis

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