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Gene Review

VPS36  -  vacuolar protein sorting 36 homolog (S....

Homo sapiens

Synonyms: C13orf9, CGI-145, EAP45, ELL-associated protein of 45 kDa, ESCRT-II complex subunit VPS36, ...
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High impact information on VPS36

  • Furthermore, we show that Eap45 colocalizes with ubiquitinated proteins on late endosomes [1].
  • Here we report the cloning of cDNAs encoding the EAP45 and EAP20 proteins [2].
  • The GLUE (GRAM-like, ubiquitin-binding on Eap45) domain extending beyond the core of the ESCRT II complex recognizes PtdIns3P-containing membranes, monoubiquitinated cargo and ESCRT I [3].
  • Here, we report that the three subunits of human ESCRT-II, EAP20, EAP30, and EAP45, have a number of properties in common with their yeast orthologs [4].
  • Furthermore, VPS36 localizes to the anterior of the oocyte in a bicoid-mRNA-dependent manner, and is required for the subsequent recruitment of Staufen to the bicoid complex [5].

Biological context of VPS36

  • Residues in two amino-terminal PPXY motifs (motif I and II), involved in dimerization of Vps25p and interaction with Vps22p and Vps36p, were closely, but not absolutely conserved [6].


  1. Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. Slagsvold, T., Aasland, R., Hirano, S., Bache, K.G., Raiborg, C., Trambaiolo, D., Wakatsuki, S., Stenmark, H. J. Biol. Chem. (2005) [Pubmed]
  2. Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. Kamura, T., Burian, D., Khalili, H., Schmidt, S.L., Sato, S., Liu, W.J., Conrad, M.N., Conaway, R.C., Conaway, J.W., Shilatifard, A. J. Biol. Chem. (2001) [Pubmed]
  3. Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies. Gill, D.J., Teo, H., Sun, J., Perisic, O., Veprintsev, D.B., Vallis, Y., Emr, S.D., Williams, R.L. Biochem. Soc. Symp. (2007) [Pubmed]
  4. Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release. Langelier, C., von Schwedler, U.K., Fisher, R.D., De Domenico, I., White, P.L., Hill, C.P., Kaplan, J., Ward, D., Sundquist, W.I. J. Virol. (2006) [Pubmed]
  5. bicoid RNA localization requires specific binding of an endosomal sorting complex. Irion, U., St Johnston, D. Nature (2007) [Pubmed]
  6. Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component. Slater, R., Bishop, N.E. BMC Evol. Biol. (2006) [Pubmed]
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