The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

VPS36  -  ESCRT-II subunit protein VPS36

Saccharomyces cerevisiae S288c

Synonyms: ESCRT-II complex subunit VPS36, GRD12, VAC3, VPL11, Vacuolar protein-sorting-associated protein 36, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on VPS36

  • We show that yeast ESCRT-I links directly to ESCRT-II, through a tight interaction of Vps28 (ESCRT-I) with the yeast-specific zinc-finger insertion within the GLUE domain of Vps36 (ESCRT-II) [1].
  • To identify the functionally relevant interacting proteins, we analyzed all of the available gene deletion mutants and found three (vps36 Delta, pep12 Delta, and tlg2 Delta) that induce STRE and also repress pheromone-dependent transcription [2].
  • A vps36 Delta mutation diminishes signaling by pheromone as well as by downstream components including the G protein, effector kinase (Ste11), and transcription factor (Ste12) [2].
  • Conversely, overexpression of Vps36 enhances the pheromone response in sst2 Delta cells but not in wild type [2].
  • In this study, we have analyzed trafficking in the endosomal system by monitoring the movement of Pma1-7 in vps36, vps1, and vps8 mutants [3].

Biological context of VPS36

  • Residues in two amino-terminal PPXY motifs (motif I and II), involved in dimerization of Vps25p and interaction with Vps22p and Vps36p, were closely, but not absolutely conserved [4].

Other interactions of VPS36

  • Upon induction of expression, mutant Pma1 accumulates in the prevacuolar compartment in vps36 cells [3].
  • Two PPXY-motifs from Vps25 are involved in contacts with Vps22 and Vps36, and their mutation leads to ESCRT-II disruption [5].


  1. ESCRT-I Core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Teo, H., Gill, D.J., Sun, J., Perisic, O., Veprintsev, D.B., Vallis, Y., Emr, S.D., Williams, R.L. Cell (2006) [Pubmed]
  2. Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae. Burchett, S.A., Flanary, P., Aston, C., Jiang, L., Young, K.H., Uetz, P., Fields, S., Dohlman, H.G. J. Biol. Chem. (2002) [Pubmed]
  3. An endosome-to-plasma membrane pathway involved in trafficking of a mutant plasma membrane ATPase in yeast. Luo, W., Chang, A. Mol. Biol. Cell (2000) [Pubmed]
  4. Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component. Slater, R., Bishop, N.E. BMC Evol. Biol. (2006) [Pubmed]
  5. ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Teo, H., Perisic, O., González, B., Williams, R.L. Dev. Cell (2004) [Pubmed]
WikiGenes - Universities