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Gene Review:

TUBE1 - tubulin, epsilon 1

Homo sapiens

Synonyms: Epsilon-tubulin, FLJ22589, TUBE, Tubulin epsilon chain, dJ142L7.2

Chang, P. et al., Nelson, W.J., Keller, L.C. et al., Chang, P. et al., Inclán, Y.F. et al., et al.

Robert Hoffmann,

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High impact information on TUBE1

This review provides a summary of these pathways based upon articles published in the Tube Morphogenesis Series in Trends in Cell Biology [1].
Epsilon-tubulin is required for centriole duplication and microtubule organization [2].
We show that recruitment of epsilon-tubulin to the new centrosome can only occur after exit from S phase and that epsilon-tubulin is associated with the sub-distal appendages of mature centrioles [2].
Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function [3].
This analysis detected the majority of known centriole proteins, including centrin, epsilon tubulin, and the cartwheel protein BLD10p [4].

Biological context of TUBE1

Depletion of epsilon-tubulin from Xenopus egg extracts blocks centriole duplication in S phase and formation of organized centrosome-independent microtubule asters in M phase [2].

Anatomical context of TUBE1

Structural models for the self-assembly and microtubule interactions of gamma-, delta- and epsilon-tubulin [5].

References

Tube morphogenesis: closure, but many openings remain. Nelson, W.J. Trends Cell Biol. (2003) [Pubmed]
Epsilon-tubulin is required for centriole duplication and microtubule organization. Chang, P., Giddings, T.H., Winey, M., Stearns, T. Nat. Cell Biol. (2003) [Pubmed]
Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. Chang, P., Stearns, T. Nat. Cell Biol. (2000) [Pubmed]
Proteomic analysis of isolated chlamydomonas centrioles reveals orthologs of ciliary-disease genes. Keller, L.C., Romijn, E.P., Zamora, I., Yates, J.R., Marshall, W.F. Curr. Biol. (2005) [Pubmed]
Structural models for the self-assembly and microtubule interactions of gamma-, delta- and epsilon-tubulin. Inclán, Y.F., Nogales, E. J. Cell. Sci. (2001) [Pubmed]

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TUBE1	Canis lupus familiaris
tube1	Danio rerio
TUBE1	Gallus gallus
TUBE1	Macaca mulatta
Tube1	Mus musculus
TUBE1	Pan troglodytes
Tube1	Rattus norvegicus
tube1	Xenopus (Silurana) tropicalis

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