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Gene Review

TUBD1  -  tubulin, delta 1

Homo sapiens

Synonyms: Delta-tubulin, FLJ12709, TUBD, Tubulin delta chain
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High impact information on TUBD1

  • One is a homologue of the Chlamydomonas delta-tubulin Uni3, and the other is a new tubulin, which we have named epsilon-tubulin [1].
  • The carboxyl terminus of a specific beta tubulin isoform plays an important role in forming the '9 + 2' structure of the axoneme; delta tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies [2].
  • The discovery of delta-tubulin, the fourth member of the tubulin superfamily, in Chlamydomonas [1] has led to the identification in the genomes of vertebrates and protozoa of putative delta homologues and of additional tubulins, epsilon and zeta [2-4] [3].
  • Analysis of mutants depleted in particular flagellar and basal body proteins [gamma-tubulin, delta-tubulin, Parkin co-regulated gene product (PACRG) or the paraflagellar rod protein PFR2] allowed a dissection of the mechanisms for central pair constraint [4].

Anatomical context of TUBD1


Analytical, diagnostic and therapeutic context of TUBD1

  • Balloon dilatation of the prostate (TUBD), besides some criticism, represents a nonoperative treatment alternative for treatment of symptomatic BPH which is simple and safe [6].


  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. Chang, P., Stearns, T. Nat. Cell Biol. (2000) [Pubmed]
  2. Motile organelles: the importance of specific tubulin isoforms. Dutcher, S.K. Curr. Biol. (2001) [Pubmed]
  3. The SM19 gene, required for duplication of basal bodies in Paramecium, encodes a novel tubulin, eta-tubulin. Ruiz, F., Krzywicka, A., Klotz, C., Keller, A., Cohen, J., Koll, F., Balavoine, G., Beisson, J. Curr. Biol. (2000) [Pubmed]
  4. Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes. Gadelha, C., Wickstead, B., McKean, P.G., Gull, K. J. Cell. Sci. (2006) [Pubmed]
  5. Cell division: The renaissance of the centriole. Marshall, W.F., Rosenbaum, J.L. Curr. Biol. (1999) [Pubmed]
  6. Transurethral balloon divulsion of prostate. Hernandez-Graulau, J.M. Urology (1993) [Pubmed]
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