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Gene Review

KLF3  -  Kruppel-like factor 3 (basic)

Homo sapiens

Synonyms: BKLF, Basic krueppel-like factor, CACCC-box-binding protein BKLF, Krueppel-like factor 3, TEF-2
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High impact information on KLF3

  • In contrast, TEF-1 and a second SV40 enhancer binding protein, TEF-2, bind independently to templates containing the cognate motifs of both proteins (GT-I and either GT-IIC or Sph motifs) even though these motifs cooperate in enhancer activity in vivo [1].
  • Basic Krüppel-like factor (BKLF) is a zinc finger protein that recognizes CACCC elements in DNA [2].
  • Finally, we show that mutation of the CtBP NADH binding site impairs the ability of the proteins to dimerize and to associate with BKLF [3].
  • Different but closely linked regions of BKLF mediate contact with CtBP2 and FHL3 [4].
  • We show here that BKLF also recruits the four and a half LIM domain protein FHL3 [4].

Biological context of KLF3


Associations of KLF3 with chemical compounds

  • Consistent with this result, we showed that mutation of the final histidine had only a modest effect on DNA binding in the context of the full three-finger DNA-binding domain of basic Krüppel-like factor [6].
  • While the majority of these changes were silent, TEF-2 and TEF-3 differed from TEF-1 by having a lysine instead of a glutamate at amino acid position 41 [7].


  1. The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence. Davidson, I., Xiao, J.H., Rosales, R., Staub, A., Chambon, P. Cell (1988) [Pubmed]
  2. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. Turner, J., Crossley, M. EMBO J. (1998) [Pubmed]
  3. Mechanisms directing the nuclear localization of the CtBP family proteins. Verger, A., Quinlan, K.G., Crofts, L.A., Spanò, S., Corda, D., Kable, E.P., Braet, F., Crossley, M. Mol. Cell. Biol. (2006) [Pubmed]
  4. The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2. Turner, J., Nicholas, H., Bishop, D., Matthews, J.M., Crossley, M. J. Biol. Chem. (2003) [Pubmed]
  5. A novel element and a TEF-2-like element activate the major histocompatibility complex class II transactivator in B-lymphocytes. Ghosh, N., Piskurich, J.F., Wright, G., Hassani, K., Ting, J.P., Wright, K.L. J. Biol. Chem. (1999) [Pubmed]
  6. CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions. Simpson, R.J., Cram, E.D., Czolij, R., Matthews, J.M., Crossley, M., Mackay, J.P. J. Biol. Chem. (2003) [Pubmed]
  7. Sequence analysis of the EF-1 alpha gene family of Mucor racemosus. Sundstrom, P., Lira, L.M., Choi, D., Linz, J.E., Sypherd, P.S. Nucleic Acids Res. (1987) [Pubmed]
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