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Gene Review

PLA1A  -  phospholipase A1 member A

Homo sapiens

Synonyms: NMD, PS-PLA1, PSPLA1, Phosphatidylserine-specific phospholipase A1, Phospholipase A1 member A, ...
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Disease relevance of PLA1A

  • In addition, human PS-PLA1 gene was mapped to chromosome 3q13.13-13.2 and was unexpectedly identical to the nmd gene, which is highly expressed in nonmetastatic melanoma cell lines but poorly expressed in metastatic cell lines (van Groningen, J. J., Bloemers, H. P., and Swart, G. W. (1995) Cancer Res. 55, 6237-6243) [1].

High impact information on PLA1A

  • Together with the phospholipase gene PSPLA1, LPDL and LPDLR form a new lipase gene subfamily, which is characterized by shortened lid motif [2].
  • In addition to an mRNA encoding a 456-amino acid product (PS-PLA1), an mRNA with four extra bases inserted at the boundary of the exon-intron junction was detected in human tissues and various human cell lines [1].
  • This mRNA is most probably produced via an alternative use of the 5'-splicing site (two consensus sequences for RNA splicing occur at the boundary of the exon-intron junction) and encodes a 376-amino acid product (PS-PLA1DeltaC) that lacks two-thirds of the C-terminal domain of PS-PLA1 [1].
  • RESULTS: BLAST database searches indicated that the predicted amino acid sequence of LL is related to phosphatidylserine phospholipase A(1) (PS-PLA1) and to members of the triacylglycerol lipase family [3].
  • Since the recently identified phosphatidylserine-specific phospholipase A1 (PS-PLA1) demonstrates significant homology to triglyceride lipases, we reasoned that the mouse Ps-plaI gene may be the disrupted gene within the lpd locus [4].

Anatomical context of PLA1A

  • However, PS-PLA1 efficiently hydrolyzes PS exposed on the surface of cells such as apoptotic cells and activated platelets, and produces 2-acyl-lysophosphatidylserine (lysoPS), which is a lipid mediator for mast cells, T cells and neural cells [5].

Associations of PLA1A with chemical compounds


Analytical, diagnostic and therapeutic context of PLA1A

  • Crystallization of organic compounds in nanometer-scale channels of controlled pore glass (CPG) and porous polystyrene (p-PS), the latter prepared by etching of the polylactide (PLA) component of shear-aligned PS-PLA diblock copolymers, produces crystals with dimensions that reflect the size constraints imposed by the channels [7].


  1. An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans. Nagai, Y., Aoki, J., Sato, T., Amano, K., Matsuda, Y., Arai, H., Inoue, K. J. Biol. Chem. (1999) [Pubmed]
  2. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Wen, X.Y., Hegele, R.A., Wang, J., Wang, D.Y., Cheung, J., Wilson, M., Yahyapour, M., Bai, Y., Zhuang, L., Skaug, J., Young, T.K., Connelly, P.W., Koop, B.F., Tsui, L.C., Stewart, A.K. Hum. Mol. Genet. (2003) [Pubmed]
  3. mRNA encoding a new lipolytic enzyme expressed in rabbit lacrimal glands. Remington, S.G., Nelson, J.D. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  4. Murine phosphatidylserine-specific phospholipase A1 (Ps-pla1) maps to chromosome 16 but is distinct from the lpd (lipid defect) locus. Wen, X.Y., Stewart, A.K., Skaug, J., Wei, E., Tsui, L.C. Mamm. Genome (2001) [Pubmed]
  5. Structure and function of phosphatidylserine-specific phospholipase A1. Aoki, J., Nagai, Y., Hosono, H., Inoue, K., Arai, H. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 ( PSPLA1). Wang, J., Wen, X.Y., Stewart, A.K., Hegele, R.A. J. Hum. Genet. (2002) [Pubmed]
  7. Thermotropic properties of organic nanocrystals embedded in ultrasmall crystallization chambers. Ha, J.M., Hillmyer, M.A., Ward, M.D. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
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