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Gene Review

ACTL6B  -  actin-like 6B

Homo sapiens

Synonyms: 53 kDa BRG1-associated factor B, ACTL6, Actin-like protein 6B, Actin-related protein Baf53b, ArpNalpha, ...
 
 
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Disease relevance of ACTL6B

 

High impact information on ACTL6B

  • These findings suggest that SWI/SNF complex containing ArpN alpha might regulate certain genes involved in brain development and/or its function differently from SWI/SNF complex containing ArpN beta/BAF53 [1].
  • The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP [1].
  • No difference was observed between ArpNalpha and beta in subcellular localization and interaction with BRM, which is an ATPase subunit of mammalian SWI/SNF chromatin remodeling complex [2].
  • ArpNalpha is the first brain-specific component of a chromatin remodeling complex to be identified, suggesting that ArpNalpha has conserved and important roles in the differentiation of neural cells through regulation of chromatin structure [2].

References

  1. The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP. Oma, Y., Nishimori, K., Harata, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  2. Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. Kuroda, Y., Oma, Y., Nishimori, K., Ohta, T., Harata, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
 
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