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Gene Review

ARP4  -  Arp4p

Saccharomyces cerevisiae S288c

Synonyms: ACT3, Actin-like protein 4, Actin-like protein ARP4, Actin-related protein 4, J1012, ...
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High impact information on ARP4


Biological context of ARP4

  • ARP4, an essential gene of Saccharomyces cerevisiae, codes for a nuclear actin-related protein [5].
  • Furthermore, the use of reporter genes confirmed that Arp4p could be involved in some general mechanism of transcriptional regulation [6].
  • The same effect was observed upon treatment with rapamycin, indicating an unexpected relationship of Arp4 to TOR-mediated cell cycle arrest [5].
  • The roles of the core actin structure (the ATP-binding pocket) and a putative Nuclear Localization Signal (NLS) of Arp4p were tested by targeted mutagenesis [6].
  • We used a mutant strain with a single amino acid substitution (G161D) in the conserved actin fold domain to investigate the influence of Arp4 on stress and nitrogen catabolite repression genes [5].

Associations of ARP4 with chemical compounds


Other interactions of ARP4

  • We have ordered the new ARPs relative to this group of actins and propose to name the more distantly related ARP members, according to their amino acid identity and similarity, Arp4-Arp10 [10].

Analytical, diagnostic and therapeutic context of ARP4


  1. Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Bird, A.W., Yu, D.Y., Pray-Grant, M.G., Qiu, Q., Harmon, K.E., Megee, P.C., Grant, P.A., Smith, M.M., Christman, M.F. Nature (2002) [Pubmed]
  2. Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus. Jiang, Y.W., Stillman, D.J. Genes Dev. (1996) [Pubmed]
  3. An essential gene of Saccharomyces cerevisiae coding for an actin-related protein. Harata, M., Karwan, A., Wintersberger, U. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere. Minoda, A., Saitoh, S., Takahashi, K., Toda, T. Mol. Biol. Cell (2005) [Pubmed]
  5. Novel Regulatory Properties of Saccharomyces cerevisiae Arp4. Steinboeck, F., Krupanska, L., Bogusch, A., Kaufmann, A., Heidenreich, E. J. Biochem. (2006) [Pubmed]
  6. Further characterization of the actin-related protein Act3p/Arp4 of S. cerevisiae through mutational analysis. Stefanov, S.A. Mol. Biol. Rep. (2000) [Pubmed]
  7. The nuclear actin-related protein Act3p/Arp4p of Saccharomyces cerevisiae is involved in transcription regulation of stress genes. Görzer, I., Schüller, C., Heidenreich, E., Krupanska, L., Kuchler, K., Wintersberger, U. Mol. Microbiol. (2003) [Pubmed]
  8. The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin-modulating complexes. Sunada, R., Görzer, I., Oma, Y., Yoshida, T., Suka, N., Wintersberger, U., Harata, M. Yeast (2005) [Pubmed]
  9. Immunochemical study on the mannans of Candida albicans NIH A-207, NIH B-792, and J-1012 strains prepared by fractional precipitation with cetyltrimethylammonium bromide. Shibata, N., Ichikawa, T., Tojo, M., Takahashi, M., Ito, N., Okubo, Y., Suzuki, S. Arch. Biochem. Biophys. (1985) [Pubmed]
  10. Who's who among the Saccharomyces cerevisiae actin-related proteins? A classification and nomenclature proposal for a large family. Poch, O., Winsor, B. Yeast (1997) [Pubmed]
  11. Correlation between chromatin association and transcriptional regulation for the Act3p/Arp4 nuclear actin-related protein of Saccharomyces cerevisiae. Harata, M., Zhang, Y., Stillman, D.J., Matsui, D., Oma, Y., Nishimori, K., Mochizuki, R. Nucleic Acids Res. (2002) [Pubmed]
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