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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Act1  -  actin related gene 1

Mus musculus

Synonyms: Act-1
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Disease relevance of Act1

  • The actin-related changes occur in platelets at temperatures below 37 degrees C, suggesting that the platelet may be more activable at temperatures at the body surface than at core temperature, thereby favoring superficial hemostasis over internal thrombosis [1].
  • We recently reported the isolation of a novel actin-related gene, Arp11, from a PC-14 human lung adenocarcinoma clone with low metastatic and tumorigenic ability [2].

Psychiatry related information on Act1


High impact information on Act1

  • We show that vertebrate neurons have a specialized chromatin remodeling complex, bBAF, specifically containing the actin-related protein, BAF53b, which is first expressed in postmitotic neurons at about murine embryonic day 12.5 (E12.5) [4].
  • Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin [5].
  • The human genome contains greater than 20 actin-related sequences, six of which at least are expressed as protein [6].
  • The binding activity of TN14 mAb with the Thy-1 molecule on T cells was strongly blocked by the addition of purified actin, indicating that TN14 mAb recognized an actin-related epitope of the Thy-1 molecule [7].
  • Number and organization of actin-related sequences in the mouse genome [8].

Biological context of Act1


Associations of Act1 with chemical compounds

  • Then we rigorously examined 'core' actin-related gene expression in the frontal cortex of C57BL/6 (B6) (prone to depression) and C3H/He (C3) (resistant to depression) mice [3].

Other interactions of Act1

  • Recombinant plasmids containing cDNA sequences complementary to the two mouse striated-muscle actin messenger RNAs (pAF81, pAM91) and to a non-muscle actin mRNA (pAL41) have been used to examine the number and organization of actin-related sequences in the mouse genome [8].


  1. Mechanisms of cold-induced platelet actin assembly. Hoffmeister, K.M., Falet, H., Toker, A., Barkalow, K.L., Stossel, T.P., Hartwig, J.H. J. Biol. Chem. (2001) [Pubmed]
  2. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. Shindo-Okada, N., Iigo, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Expression analysis of actin-related genes as an underlying mechanism for mood disorders. Nakatani, N., Ohnishi, T., Iwamoto, K., Watanabe, A., Iwayama, Y., Yamashita, S., Ishitsuka, Y., Moriyama, K., Nakajima, M., Tatebayashi, Y., Akiyama, H., Higuchi, T., Kato, T., Yoshikawa, T. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  4. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Olave, I., Wang, W., Xue, Y., Kuo, A., Crabtree, G.R. Genes Dev. (2002) [Pubmed]
  5. Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin. Melki, R., Vainberg, I.E., Chow, R.L., Cowan, N.J. J. Cell Biol. (1993) [Pubmed]
  6. Actin-like sequences are present on human X and Y chromosomes. Heilig, R., Hanauer, A., Grzeschik, K.H., Hors-Cayla, M.C., Mandel, J.L. EMBO J. (1984) [Pubmed]
  7. Monoclonal antibody against actin cross-reacts with the Thy-1 molecule and inhibits lymphocyte function-associated antigen-1 dependent cell-cell interaction of T cells. Nishimura, T., Takeuchi, Y., Gao, X.H., Urano, K., Habu, S. J. Immunol. (1991) [Pubmed]
  8. Number and organization of actin-related sequences in the mouse genome. Minty, A.J., Alonso, S., Guénet, J.L., Buckingham, M.E. J. Mol. Biol. (1983) [Pubmed]
  9. Genomic structure and promoter activity of the testis haploid germ cell-specific intronless genes, Tact1 and Tact2. Hisano, M., Yamada, S., Tanaka, H., Nishimune, Y., Nozaki, M. Mol. Reprod. Dev. (2003) [Pubmed]
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