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Gene Review

ACTL6A  -  actin-like 6A

Homo sapiens

Synonyms: 53 kDa BRG1-associated factor A, ACTL6, ARPN-BETA, Actin-like protein 6A, Actin-related protein Baf53a, ...
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Disease relevance of ACTL6A


High impact information on ACTL6A

  • BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation [2].
  • When overexpressed in HeLa or 293T cells, the subdomain Ib or IIb hybrids, in which the subdomain Ib or IIb of hArpNbeta was replaced with that of beta-actin, respectively, showed no effect on cell survival [3].
  • hArpNbeta, an actin-related protein located within the nucleus, is a subunit of the human SWI/SNF chromatin remodeling complex. hArpNbeta has been proposed to regulate the assembly and activity of the hSWI/SNF complex [3].
  • These results indicate that the proper function of hArpNbeta is essential for cell survival in human cells [3].
  • On the other hand, the overexpression of the N-terminal deletion mutant of hArpNbeta resulted in cell death probably through apoptotic process [3].

Biological context of ACTL6A


Anatomical context of ACTL6A

  • Previously we showed that over-expression of an N-terminal deletion mutant of BAF53 (BAF53_deltaN) reduced the viability of HEK293 and HeLa cells [5].

Associations of ACTL6A with chemical compounds


Other interactions of ACTL6A


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