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Gene Review

TDP2  -  tyrosyl-DNA phosphodiesterase 2

Homo sapiens

Synonyms: 5'-Tyr-DNA phosphodiesterase, 5'-tyrosyl-DNA phosphodiesterase, AD-022, AD022, EAP2, ...
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Disease relevance of TTRAP

  • We conclude that the modified EAP regimen (EAP-2) is effective in the treatment of gastric cancer and is less toxic than the original EAP [1].

Psychiatry related information on TTRAP


High impact information on TTRAP

  • 2. Our association study implicates a 77-kb region spanning the gene TTRAP and the first four exons of the neighboring uncharacterized gene KIAA0319 [3].
  • EAPII interacts with ETS1 and modulates its transcriptional function [4].
  • Significantly, re-expression of EAPII inhibits the migration of epithelial cancer cells, but does not affect cell viability [4].
  • EAP-2 consisted of i.v. adriamycin 40 mg/m2 on day 1, i.v. cisplatin 80 mg/m2 (total dose per cycle) given in 3 divided doses on days 1-3 and i.v. VP-16 100 mg/m2 on days 1-3 [1].
  • This potential novel function of TTRAP raises the intriguing possibility for a role of APE1-like DNA-repair endonucleases in TNF receptor family-mediated signaling and functions [5].

Biological context of TTRAP


Associations of TTRAP with chemical compounds


Analytical, diagnostic and therapeutic context of TTRAP


  1. Treatment of gastric adenocarcinoma with the combination of etoposide, adriamycin and cisplatin (EAP): comparison between two schedules. Haim, N., Tsalik, M., Robinson, E. Oncology (1994) [Pubmed]
  2. The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Paracchini, S., Thomas, A., Castro, S., Lai, C., Paramasivam, M., Wang, Y., Keating, B.J., Taylor, J.M., Hacking, D.F., Scerri, T., Francks, C., Richardson, A.J., Wade-Martins, R., Stein, J.F., Knight, J.C., Copp, A.J., Loturco, J., Monaco, A.P. Hum. Mol. Genet. (2006) [Pubmed]
  3. A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. Francks, C., Paracchini, S., Smith, S.D., Richardson, A.J., Scerri, T.S., Cardon, L.R., Marlow, A.J., MacPhie, I.L., Walter, J., Pennington, B.F., Fisher, S.E., Olson, R.K., DeFries, J.C., Stein, J.F., Monaco, A.P. Am. J. Hum. Genet. (2004) [Pubmed]
  4. EAPII interacts with ETS1 and modulates its transcriptional function. Pei, H., Yordy, J.S., Leng, Q., Zhao, Q., Watson, D.K., Li, R. Oncogene (2003) [Pubmed]
  5. Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases. Rodrigues-Lima, F., Josephs, M., Katan, M., Cassinat, B. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Determination of the biological response modifier MVE-2 (AD-022) in biological fluids by high-performance liquid chromatography. Rosenblum, M.G., Hersh, E.M., Loo, T.L. J. Chromatogr. (1983) [Pubmed]
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