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Gene Review

KDM3B  -  lysine (K)-specific demethylase 3B

Homo sapiens

Synonyms: 5qNCA, C5orf7, JHDM2B, JMJD1B, JmjC domain-containing histone demethylation protein 2B, ...
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Disease relevance of JMJD1B


High impact information on JMJD1B

  • Expression of 5qNCA in a del(5q) cell line results in suppression of clonogenic growth [1].
  • We propose 5qNCA is a good candidate for the del(5q) tumor suppressor gene based on its predicted function and growth suppressive activities, and suggest that further mutational and functional study of this interesting gene is warranted [1].
  • 5qNCA expresses a 7.2-kb transcript with a 5286-bp open reading frame which is present at high levels in heart, skeletal muscle, kidney, placenta, and liver as well as CD34+ cells and AML cell lines [1].
  • 5qNCA encodes a 191-kD nuclear protein which contains a highly-conserved C-terminus containing a zinc finger with the unique spacing Cys-X2-Cys-X7-His-X2-Cys-X2-Cys-X4-Cys-X2-Cys and a jmjC domain, which is often found in proteins that regulate chromatin remodeling [1].


  1. A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31. Hu, Z., Gomes, I., Horrigan, S.K., Kravarusic, J., Mar, B., Arbieva, Z., Chyna, B., Fulton, N., Edassery, S., Raza, A., Westbrook, C.A. Oncogene (2001) [Pubmed]
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