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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rgs14  -  regulator of G-protein signaling 14

Mus musculus

Synonyms: RAP1/RAP2-interacting protein, RGS14, RPIP1, Rap1/rap2 interacting protein, Regulator of G-protein signaling 14
 
 
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High impact information on Rgs14

  • Galphai2 be rendered sensitive to RGS14 GDI activity by replacement of residues within the alpha-helical domain [1].
  • RGS14 regulates G protein nucleotide exchange and hydrolysis by acting as a GAP through its RGS domain and as a guanine nucleotide dissociation inhibitor (GDI) through its GoLoco motif [1].
  • We found that RGS14 inhibits guanine nucleotide exchange on Galphai1 and Galphai3 could, but not Galphai2 [1].
  • The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2 [2].
 

Analytical, diagnostic and therapeutic context of Rgs14

  • The spatiotemporal expression patterns of RGS12 and RGS14 proteins were examined by immunohistochemistry in a developmental series of postimplantation mouse embryo [3].

References

  1. The RGS14 GoLoco domain discriminates among Galphai isoforms. Mittal, V., Linder, M.E. J. Biol. Chem. (2004) [Pubmed]
  2. Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter. Garzón, J., Rodríguez-Muñoz, M., Sánchez-Blázquez, P. Neuropharmacology (2005) [Pubmed]
  3. Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development. Martin-McCaffrey, L., Hains, M.D., Pritchard, G.A., Pajak, A., Dagnino, L., Siderovski, D.P., D'Souza, S.J. Dev. Dyn. (2005) [Pubmed]
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