Gene Review:
Gnai2 - guanine nucleotide binding protein (G...
Mus musculus
Synonyms:
Adenylate cyclase-inhibiting G alpha protein, C76432, Galphai2, Gia, Gnai-2, ...
- A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models. Borm, M.E., He, J., Kelsall, B., Peña, A.S., Strober, W., Bouma, G. Gastroenterology (2005)
- Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells. Zhang, L., Tetrault, J., Wang, W., Loh, H.H., Law, P.Y. Mol. Pharmacol. (2006)
- Impaired B cell responses to orally administered antigens in lamina propria but not Peyer's patches of Galphai2-deficient mice prior to colitis. Ohman, L., Aström, R.G., Hultgren Hörnquist, E. Immunology (2005)
- Enhanced pro-inflammatory cytokine production in Galphai2-deficient mice on colitis prone and colitis resistant 129Sv genetic backgrounds. Bjursten, M., Hultgren, O.H., Hultgren Hörnquist, E. Cell. Immunol. (2004)
- Rgs1 and Gnai2 regulate the entrance of B lymphocytes into lymph nodes and B cell motility within lymph node follicles. Han, S.B., Moratz, C., Huang, N.N., Kelsall, B., Cho, H., Shi, C.S., Schwartz, O., Kehrl, J.H. Immunity (2005)
- Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Gao, M., Ping, P., Post, S., Insel, P.A., Tang, R., Hammond, H.K. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Huang, X., Fu, Y., Charbeneau, R.A., Saunders, T.L., Taylor, D.K., Hankenson, K.D., Russell, M.W., D'Alecy, L.G., Neubig, R.R. Mol. Cell. Biol. (2006)
- Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells. Watts, V.J., Wiens, B.L., Cumbay, M.G., Vu, M.N., Neve, R.L., Neve, K.A. J. Neurosci. (1998)
- Long-term treatment with anti-alpha 4 integrin antibodies aggravates colitis in G alpha i2-deficient mice. Bjursten, M., Bland, P.W., Willén, R., Hörnquist, E.H. Eur. J. Immunol. (2005)
- B cell developmental requirement for the G alpha i2 gene. Dalwadi, H., Wei, B., Schrage, M., Spicher, K., Su, T.T., Birnbaumer, L., Rawlings, D.J., Braun, J. J. Immunol. (2003)
- Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. Wei, B., Velazquez, P., Turovskaya, O., Spricher, K., Aranda, R., Kronenberg, M., Birnbaumer, L., Braun, J. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Conditional, tissue-specific expression of Q205L Galphai2 in vivo mimics insulin activation of c-Jun N-terminal kinase and p38 kinase. Guo, J.H., Wang, H.Y., Malbon, C.C. J. Biol. Chem. (1998)
- Signaling through G{alpha}i2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice. Padigel, U.M., Stein, L., Redding, K., Lee, J.J., Nolan, T.J., Schad, G.A., Birnbaumer, L., Abraham, D. J. Leukoc. Biol. (2007)
- Coupling of GABAB receptor GABAB2 subunit to G proteins: evidence from Xenopus oocyte and baby hamster kidney cell expression system. Uezono, Y., Kanaide, M., Kaibara, M., Barzilai, R., Dascal, N., Sumikawa, K., Taniyama, K. Am. J. Physiol., Cell Physiol. (2006)
- Formation of B and T cell subsets require the cannabinoid receptor CB2. Ziring, D., Wei, B., Velazquez, P., Schrage, M., Buckley, N.E., Braun, J. Immunogenetics (2006)
- Distinct roles for Galphai2, Galphai3, and Gbeta gamma in modulation offorskolin- or Gs-mediated cAMP accumulation and calcium mobilization by dopamine D2S receptors. Ghahremani, M.H., Cheng, P., Lembo, P.M., Albert, P.R. J. Biol. Chem. (1999)
- The RGS14 GoLoco domain discriminates among Galphai isoforms. Mittal, V., Linder, M.E. J. Biol. Chem. (2004)
- TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit. Huang, T.T., Zong, Y., Dalwadi, H., Chung, C., Miceli, M.C., Spicher, K., Birnbaumer, L., Braun, J., Aranda, R. Int. Immunol. (2003)
- Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex. Schüller, U., Lamp, E.C., Schilling, K. Histochem. Cell Biol. (2001)
- The rat D4 dopamine receptor couples to cone transducin (Galphat2) to inhibit forskolin-stimulated cAMP accumulation. Yamaguchi, I., Harmon, S.K., Todd, R.D., O'Malley, K.L. J. Biol. Chem. (1997)
- RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Galphaz subunits. Sánchez-Blázquez, P., Rodríguez-Muñoz, M., Montero, C., Garzón, J. Neuropharmacology (2005)
- Transfer of colitis by Galphai2-deficient T lymphocytes: impact of subpopulations and tissue origin. Bjursten, M., Willén, R., Hultgren Hörnquist, E. Inflamm. Bowel Dis. (2005)
- Modulation of adenylyl cyclase by FPP and adenosine involves stimulatory and inhibitory adenosine receptors and g proteins. Fraser, L.R., Adeoya-Osiguwa, S. Mol. Reprod. Dev. (1999)