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Gene Review

Rgs17  -  regulator of G-protein signaling 17

Mus musculus

Synonyms: 6430507P11Rik, RGS17, RGSZ2, Regulator of G-protein signaling 17, Regulator of Gz-selective protein signaling 2, ...
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High impact information on Rgs17

  • RGS17 is a new RZ member that preferentially inhibits receptor signaling via G(i/o), G(z), and G(q) over G(s) to enhance cAMP-dependent signaling and inhibit calcium signaling [1].
  • We have found that in the central nervous system (CNS), the levels of RGSZ2 mRNA and protein are elevated in the hypothalamus, midbrain, and pons-medulla, and that RGSZ2 is glycosylated in synaptosomal membranes isolated from CNS tissue [2].
  • In membranes from periaqueductal gray matter (PAG), both RGSZ2 and the related RGS20(Z1) co-precipitated with mu-opioid receptors [2].
  • In contrast, the knockdown of RGSZ2 proteins did not affect the activity of delta receptor agonists, [D-Pen2,5]-enkephalin (DPDPE), and [D-Ala2] deltorphin II [2].
  • In analyzing the function of RGSZ2 in the CNS, we found that when the expression of RGSZ2 was impaired, the antinociceptive response to morphine and [D-Ala2, N-MePhe4, Gly-ol5]-enkephalin (DAMGO) augmented [2].

Biological context of Rgs17

  • In contrast, analysis of the medial frontal cortex (MFC) revealed a significant decrease in Rgs17 expression exclusively, and a modest up-regulation of Rgs5 transcript [3].

Other interactions of Rgs17

  • The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2 [4].


  1. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. Mao, H., Zhao, Q., Daigle, M., Ghahremani, M.H., Chidiac, P., Albert, P.R. J. Biol. Chem. (2004) [Pubmed]
  2. The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins. Garzón, J., Rodríguez-Muñoz, M., López-Fando, A., Sánchez-Blázquez, P. Neuropsychopharmacology (2005) [Pubmed]
  3. Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signalling (Rgs) transcripts. Stanwood, G.D., Parlaman, J.P., Levitt, P. Eur. J. Neurosci. (2006) [Pubmed]
  4. Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter. Garzón, J., Rodríguez-Muñoz, M., Sánchez-Blázquez, P. Neuropharmacology (2005) [Pubmed]
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