High impact information on PEPB

• Linkage group 3 comprises PEP-B (peptidase B), MPI-1 (mannosephosphate isomerase), SORD (sorbitol dehydrogenase), and mIDH-2 (mitochondrial isocitrate dehydrogenase) [1].
• These results are consistent with the OCU-HSA chromosome homoeologies previously reported, except for PEPB [2].
• Their gene pool shows a peptidase B variant (PEPB2BAN1) and "private" polymorphism of carbonic anhydrase2 (CA2BAN1) until now observed only among them [3].
• Three private polymorphisms, at the 2,3-diphosphoglycerate mutase, peptidase B, and purine nucleoside phosphorylase loci, have been observed, which may be useful in future studies of genetic relationships between Eskimos and other circumpolar populations [4].
• Two "private polymorphisms" were encountered, of PEPB in the Pano and CAII in the Baniwa [5].

Biological context of PEPB

• The statistical map, in general, agrees with the cytogenetic map and further localizes PEPB to 12q21 [6].

Anatomical context of PEPB

• This paper presents the results of an electrophoretic survey of approximately 4000 individuals from Hiroshima and Nagasaki for four erythrocyte enzymes: isocitrate dehydrogenase, peptidase A, peptidase B, and phosphohexose isomerase [7].
• In lymphocyte cultures 9% of the cells had either no or two rings, but the patient's RBC had normal activities of the enzymes lactate dehydrogenase B and peptidase B, whose loci are located on the proximal portions of 12p and 12q, respectively [8].

References