Gene Review:
PGGT1B - protein geranylgeranyltransferase type I,...
Homo sapiens
Synonyms:
BGGI, GGTI, GGTase-I-beta, Geranylgeranyl transferase type I subunit beta, Geranylgeranyl transferase type-1 subunit beta, ...
- Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Lobell, R.B., Omer, C.A., Abrams, M.T., Bhimnathwala, H.G., Brucker, M.J., Buser, C.A., Davide, J.P., deSolms, S.J., Dinsmore, C.J., Ellis-Hutchings, M.S., Kral, A.M., Liu, D., Lumma, W.C., Machotka, S.V., Rands, E., Williams, T.M., Graham, S.L., Hartman, G.D., Oliff, A.I., Heimbrook, D.C., Kohl, N.E. Cancer Res. (2001)
- Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. Rattan, R., Giri, S., Singh, A.K., Singh, I. Free Radic. Biol. Med. (2003)
- The role of geranylgeranylated proteins in human mesangial cell proliferation. Khwaja, A., Sharpe, C.C., Noor, M., Hendry, B.M. Kidney Int. (2006)
- Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors. Morgan, M.A., Wegner, J., Aydilek, E., Ganser, A., Reuter, C.W. Leukemia (2003)
- Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Morgan, M.A., Sebil, T., Aydilek, E., Peest, D., Ganser, A., Reuter, C.W. Br. J. Haematol. (2005)
- Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Veillard, N.R., Braunersreuther, V., Arnaud, C., Burger, F., Pelli, G., Steffens, S., Mach, F. Atherosclerosis (2006)
- Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells. Rung, E., Friberg, P.A., Bergh, C., Billig, H. Mol. Reprod. Dev. (2006)
- Evaluating the therapeutic approach in pregnancies complicated by borderline glucose intolerance: a randomized clinical trial. Bonomo, M., Corica, D., Mion, E., Gonçalves, D., Motta, G., Merati, R., Ragusa, A., Morabito, A. Diabet. Med. (2005)
- Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. Tang, D., Park, H.J., Georgescu, S.P., Sebti, S.M., Hamilton, A.D., Galper, J.B. Life Sci. (2006)