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PI4KA  -  phosphatidylinositol 4-kinase, catalytic,...

Homo sapiens

Synonyms: PI4-kinase alpha, PI4K-ALPHA, PI4K-alpha, PIK4, PIK4CA, ...
 
 
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High impact information on PIK4CA

  • PI4K alpha has more distant sequence homology to the catalytic domains of mammalian and yeast PtdIns 3-kinases and to the yeast Tor family of proteins [1].
  • The enzymatic properties of the protein expressed in insect cells are characteristic of type II PtdIns 4-kinases (activated by detergent and inhibited by adenosine), and PI4K alpha is recognized by an antibody specific for type II PtdIns 4-kinases [1].
  • Screening of two functional domains of PIK4CA and the promoter region resulted in the identification of 15 different polymorphisms [2].
  • Polymorphism screening of PIK4CA: possible candidate gene for chromosome 22q11-linked psychiatric disorders [2].
  • One is PIK4CA, a member of the phosphatidylinositol 4-kinase family that phosphorylates PtdIns at the D4 position of the inositol ring as part of the PtdIns-4,5-P(2) synthetic pathway [2].

References

  1. Cloning and characterization of a human phosphatidylinositol 4-kinase. Wong, K., Cantley, L.C. J. Biol. Chem. (1994) [Pubmed]
  2. Polymorphism screening of PIK4CA: possible candidate gene for chromosome 22q11-linked psychiatric disorders. Saito, T., Stopkova, P., Diaz, L., Papolos, D.F., Boussemart, L., Lachman, H.M. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003) [Pubmed]
 
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