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Gene Review:

3B1 - DNA segment, 3B1 Research Genetics

Mus musculus

Osheroff, P.L. et al., Meyer-Puttlitz, B. et al., Pérez, J. et al., Hencsey, Z. et al.

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High impact information on 3B1

An in vivo passage of uncloned 3-1B cells yielded hybridoma cells (presumably a subclone), designated 3B1, the supernatant of which exhibited interferon-like antiviral activity with both bovine kidney (MDBK) cells and human amnion (WISH) cells [1].
The N-terminal fragments of neurocan are also recognized by monoclonal antibodies (5C4, 8A4, and 3B1) to epitopes in the G1 and G2 domains of aggrecan and/or in the hyaluronic acid-binding domain of link protein [2].
Two murine hybridoma cell lines named 1D12 and 3B1 secreting antibody against human blood group B were developed [3].

Analytical, diagnostic and therapeutic context of 3B1

Mab 3E6 displays immunoblotting properties that are similar to those of a polyclonal antibody against the pool of glycoproteins from RF, but that are different from those of Mabs 3B1 and 2A5 [4].

References

Interferon-like activity in an anti-interferon anti-idiotypic hybridoma antibody. Osheroff, P.L., Chiang, T.R., Manousos, D. J. Immunol. (1985) [Pubmed]
Chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of nervous tissue: developmental changes of neurocan and phosphacan. Meyer-Puttlitz, B., Milev, P., Junker, E., Zimmer, I., Margolis, R.U., Margolis, R.K. J. Neurochem. (1995) [Pubmed]
Effect of medium composition on hybridoma growth and antibody production. Hencsey, Z., Fizil, A., Inzelt-Kovács, M., Veszely, G., Bánkúti, L. Acta microbiologica et immunologica Hungarica. (1996) [Pubmed]
Bovine Reissner's fiber (RF) and the central canal of the spinal cord: an immunocytochemical study using a set of monoclonal antibodies against the RF-glycoproteins. Pérez, J., Garrido, O., Cifuentes, M., Alonso, F.J., Estivill-Torrús, G., Eller, G., Nualart, F., López-Avalos, M.D., Fernández-Llebrez, P., Rodríguez, E.M. Cell Tissue Res. (1996) [Pubmed]

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