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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BTBD1  -  BTB (POZ) domain containing 1

Homo sapiens

Synonyms: BTB/POZ domain-containing protein 1, C15orf1, HCV NS5A-transactivated protein 8, Hepatitis C virus NS5A-transactivated protein 8, NS5ATP8
 
 
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High impact information on BTBD1

  • The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation [1].
  • The BTBD1 protein was recently cloned on the basis of its interaction with the core domain of Topo1 and is expressed particularly in skeletal muscle [1].
  • The proliferation speed of Delta-BTBD1 C2C12 cells was significantly decreased and no myogenic differentiation was observed, although these cells maintained their capacity to enter adipocyte differentiation [1].
  • In a number of mouse and human cells, BTBD1 and BTBD2 (BTBD1/2) colocalized to punctate or elongated cytoplasmic bodies (< 5 microm long and several per cell) that were larger and more elongated in cancer cell lines than in fibroblasts and myoblasts [2].
  • BTBD1 was mapped to chromosome 15q24 [3].
 

Biological context of BTBD1

 

Other interactions of BTBD1

  • We previously identified BTBD1 and BTBD2 as novel topoisomerase I-interacting proteins that share 80% amino acid identity [2].
 

Analytical, diagnostic and therapeutic context of BTBD1

References

  1. The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation. Pisani, D.F., Cabane, C., Derijard, B., Dechesne, C.A. Cell Death Differ. (2004) [Pubmed]
  2. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Xu, L., Yang, L., Moitra, P.K., Hashimoto, K., Rallabhandi, P., Kaul, S., Meroni, G., Jensen, J.P., Weissman, A.M., D'Arpa, P. Exp. Cell Res. (2003) [Pubmed]
  3. Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24. Carim-Todd, L., Sumoy, L., Andreu, N., Estivill, X., Escarceller, M. Gene (2001) [Pubmed]
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