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Gene Review

Chst3  -  carbohydrate (chondroitin 6/keratan)...

Mus musculus

Synonyms: C6ST, C6ST-1, C6st, Carbohydrate sulfotransferase 3, Chondroitin 6-O-sulfotransferase 1, ...
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High impact information on Chst3

  • A nearly complete removal of N-glycans of the recombinant C6ST-1 by peptide N-glycosidase F increased the C6ST activity but decreased the KSST activity [1].
  • Treatment with tunicamycin of COS-7 cells transfected with C6ST-1 cDNA totally abolished production of the active C6ST-1 [1].
  • Wild-type recombinant C6ST-1 showed a typical Golgi localization, whereas M-4 recombinant C6ST-1, in which the fourth N-glycosylation site was deleted, colocalized with calnexin, an endoplasmic reticulum-resident protein [1].
  • Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin [2].
  • Despite the disappearance of chondroitin sulfate D structure, brain development was normal in the C6st(-/-) mice [2].

Biological context of Chst3


Anatomical context of Chst3

  • Further analysis revealed that the number of CD62L(+)CD44(low) T lymphocytes corresponding to naive T lymphocytes in the spleen of 5-6-week-old C6st(-/-) mice was significantly decreased, whereas those in other secondary lymphoid organs were unchanged [2].


  1. N-linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, Golgi localization, and sulfotransferase activity toward keratan sulfate. Yusa, A., Kitajima, K., Habuchi, O. J. Biol. Chem. (2006) [Pubmed]
  2. Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates. Uchimura, K., Kadomatsu, K., Nishimura, H., Muramatsu, H., Nakamura, E., Kurosawa, N., Habuchi, O., El-Fasakhany, F.M., Yoshikai, Y., Muramatsu, T. J. Biol. Chem. (2002) [Pubmed]
  3. Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Uchimura, K., Kadomatsu, K., Fan, Q.W., Muramatsu, H., Kurosawa, N., Kaname, T., Yamamura, K., Fukuta, M., Habuchi, O., Muramatsu, T. Glycobiology (1998) [Pubmed]
  4. Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family. Hemmerich, S., Lee, J.K., Bhakta, S., Bistrup, A., Ruddle, N.R., Rosen, S.D. Glycobiology (2001) [Pubmed]
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